iPTMnet Report for P49427 (CDC34)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49427 / UB2R1_HUMAN
Protein Name Ubiquitin-conjugating enzyme E2 R1
Gene Name Name: CDC34
Synonyms:UBCH3,UBE2R1;
Organism Homo sapiens (Human)

PRO ID PR:P49427
DAG View
PRO Name ubiquitin-conjugating enzyme E2 R1 (human)
Definition A ubiquitin-conjugating enzyme E2 R1 that is encoded in the genome of human.
Short Label hCDC34
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49427 (CDC34) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
Y68 Phosphorylation HPRD   PhosphoSitePlus 20068231
S71 Phosphorylation HPRD   PhosphoSitePlus 20068231
T89 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
T162 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus   RLIMS-P+ 27786305
R166 Methylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
T186 O-Glycosylation GlyGen 28657654
Y190 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
S203 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11546811, 16123592, 17461777
S222 Phosphorylation P67870 (CSNK2B) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11546811, 16123592, 17461777
S231 Phosphorylation P67870 (CSNK2B) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17461777, 11546811, 16123592, ...12037680
T233 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11546811, 16123592
S236 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11546811, 16123592, 12037680


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K18 T18 Biomuta DOID:363 / uterine cancer [ icgc ]
T186 A186 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T186 M186 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]