iPTMnet Report for P49366 (DHPS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49366 / DHYS_HUMAN
Protein Name Deoxyhypusine synthase
Gene Name Name: DHPS
Synonyms:DS;
Organism Homo sapiens (Human)

PRO ID PR:P49366
DAG View
PRO Name deoxyhypusine synthase (human)
Definition A deoxyhypusine synthase that is encoded in the genome of human.
Short Label hDHPS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49366 (DHPS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
R38 Methylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S78 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 20068231
T88 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S105 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
T202 Phosphorylation RLIMS-P 32989218
K205 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus   RLIMS-P 32989218
C275 Methylation IEDB 31844290
K329 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation HPRD 17525332, 18077418, 20068231
T88 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation HPRD 17525332, 18077418, 20068231
T88 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
T22 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 F4 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S78 P78 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic ]
S233 R233 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C275 Y275 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]