iPTMnet Report for P49321 (NASP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49321 / NASP_HUMAN
Protein Name Nuclear autoantigenic sperm protein
Gene Name Name: NASP
Organism Homo sapiens (Human)

PRO ID PR:P49321
DAG View
PRO Name nuclear autoantigenic sperm protein (human)
Definition A nuclear autoantigenic sperm protein that is encoded in the genome of human.
Short Label hNASP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49321 (NASP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K20 Acetylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K33 Acetylation PhosphoSitePlus   UniProt 19608861
K33 Ubiquitination PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S127 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
E138 Phosphorylation UniProt 21406692, 20068231
R140 Methylation PhosphoSitePlus
E141 Phosphorylation UniProt 21406692, 17081983, 20068231
Y148 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus   UniProt 23186163
S176 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
S176 Phosphorylation PhosphoSitePlus   UniProt 23186163
K180 Acetylation PhosphoSitePlus
S189 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S191 Phosphorylation PhosphoSitePlus   UniProt 23186163
T202 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
T228 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K231 Ubiquitination PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S246 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
C254 S-Nitrosylation dbSNO 26338901
S269 Phosphorylation IEDB   PhosphoSitePlus 35494241
T291 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
T291 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus   UniProt 23186163
S321 Phosphorylation PhosphoSitePlus   UniProt 21406692
S344 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
T390 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 16964243, ...15302935, 18669648, 23186163
T396 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus   UniProt 23186163
T402 O-Glycosylation GlyGen 30379171, 33465208
T402 Phosphorylation PhosphoSitePlus
T404 O-Glycosylation GlyGen 30379171, 33465208
K405 Ubiquitination PhosphoSitePlus
S408 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
S408 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
K413 Ubiquitination PhosphoSitePlus
K417 Acetylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
S421 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 15302935, ...21406692, 18669648
T425 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K426 Ubiquitination PhosphoSitePlus
S428 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S432 Phosphorylation phospho.ELM 18669648
K442 Ubiquitination PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
S451 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 21406692, 17081983, ...20068231
K455 Acetylation PhosphoSitePlus
T464 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 21406692
T477 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 17287340, ...17081983
S480 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 17287340, ...17081983
T490 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S497 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 17287340, ...20068231
S503 Phosphorylation PhosphoSitePlus   UniProt 21406692, 17081983, 24275569, ...19690332, 20068231
T534 Phosphorylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
Y575 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S608 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
R617 Methylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
K636 Sumoylation PhosphoSitePlus
K643 Acetylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus   UniProt 23186163
K671 Ubiquitination PhosphoSitePlus
T673 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
S677 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 31373491, 32119511, 30620550, 33465208, 29237092
S678 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32938750, 35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
T679 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 31373491, 32119511, 30620550, 33465208, 29237092
S680 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 31373491, 32119511, 30620550, 33465208, 29237092
T683 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
T683 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S689 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 31373491, 32119511, 30620550, 33465208, 29237092
S689 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S690 O-Glycosylation GlyGen 30379171
S690 Phosphorylation PhosphoSitePlus
S692 O-Glycosylation GlyGen 31373491
S696 O-Glycosylation GlyGen 31373491
S696 Phosphorylation PhosphoSitePlus
K698 Acetylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
T700 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus   UniProt 23186163
S706 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
S706 Phosphorylation PhosphoSitePlus   UniProt 23186163
C708 Methylation IEDB 31844290
T710 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 29351928, 34725712, 26853435, 34019948, 35254053, 35132862, 31492838, 32119511, 30620550, 33465208, 29237092
S713 Phosphorylation PhosphoSitePlus
K721 Methylation PhosphoSitePlus
S726 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983
K733 Acetylation PhosphoSitePlus
K734 Acetylation PhosphoSitePlus
K736 Acetylation PhosphoSitePlus
K736 Sumoylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus   UniProt 23186163
S751 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S756 Phosphorylation PhosphoSitePlus   UniProt 23186163
C788 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation HPRD 19413330
T123 Phosphorylation HPRD 19651622, 19664994, 17081983, ...20068231, 18452278
S127 Phosphorylation HPRD 19651622, 19664994, 20068231, ...18452278
S164 Phosphorylation HPRD 20068231
S189 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S210 Phosphorylation HPRD 19664994, 18452278
T228 Phosphorylation HPRD 17287340
S244 Phosphorylation HPRD 18669648, 19664994, 17081983
S246 Phosphorylation HPRD 19664994
T248 Phosphorylation HPRD 19651622
T390 Phosphorylation HPRD 15302935, 18669648, 17287340, ...16964243
S408 Phosphorylation HPRD 18669648
S421 Phosphorylation HPRD 17322306, 19413330, 18077418, ...18669648, 20068231
T425 Phosphorylation HPRD 18669648
S428 Phosphorylation HPRD 18669648
S432 Phosphorylation HPRD 18669648
T448 Phosphorylation HPRD 20068231
S451 Phosphorylation HPRD 19651622, 17525332, 20068231
T464 Phosphorylation HPRD 17525332, 19664994, 18077418
T477 Phosphorylation HPRD 19651622, 17287340, 17081983, ...20068231, 18452278
S480 Phosphorylation HPRD 19651622, 17287340, 17081983, ...20068231, 18452278
T490 Phosphorylation HPRD 19651622, 20068231
S497 Phosphorylation HPRD 19413330, 19651622, 17287340, ...20068231
S503 Phosphorylation HPRD 19651622, 19664994, 17081983, ...20068231, 18452278
T683 Phosphorylation HPRD 18669648
S689 Phosphorylation HPRD 18669648
S726 Phosphorylation HPRD 17322306, 19651622, 17287340, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation HPRD 19413330
T123 Phosphorylation HPRD 20068231
S127 Phosphorylation HPRD 20068231
T138 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...18452278
S141 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...18452278
T151 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S158 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19651622, 20068231
S164 Phosphorylation HPRD 19651622, 19664994, 17081983, ...20068231, 18452278
T344 Phosphorylation HPRD 18669648
S350 Phosphorylation HPRD 18669648
S387 Phosphorylation HPRD 17322306, 19651622, 17287340, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
K33 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 C28 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S36 I36 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K76 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R140 M140 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S141 L141 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S164 C164 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K180 R180 Biomuta DOID:363 / uterine cancer [ icgc ]
C254 Y254 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S269 N269 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
T291 I291 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S299 F299 Biomuta DOID:4159 / skin cancer [ cosmic ]
S387 T387 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S387 C387 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T404 R404 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K417 E417 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S451 A451 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S480 L480 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S503 C503 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R617 K617 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K643 R643 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S726 T726 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S726 C726 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S756 L756 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]