Protein Information

Cytoscape View

UniProt AC / UniProt ID P49257 / LMAN1_HUMAN
Protein Name Protein ERGIC-53 precursor
Gene Name Name: LMAN1
Organism Homo sapiens (Human)

PRO ID PR:P49257
DAG View
PRO Name protein ERGIC-53 (human)
Definition A protein ERGIC-53 that is encoded in the genome of human.
Short Label hLMAN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P49257 (LMAN1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K49 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T276 O-Glycosylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
T385 O-Glycosylation PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
S425 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
S425 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
Y430 Phosphorylation PhosphoSitePlus
T432 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
T433 O-Glycosylation GlyGen   PhosphoSitePlus 30459171, 29237092, 30397120
K440 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T276 R276 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K302 N302 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K372 E372 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T385 N385 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T391 N391 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ]
T395 N395 Biomuta DOID:3571 / liver cancer [ icgc ]
T432 K432 Biomuta DOID:3571 / liver cancer [ icgc ]