iPTMnet Report for P49257 (LMAN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49257 / LMAN1_HUMAN
Protein Name Protein ERGIC-53 precursor
Gene Name Name: LMAN1
Synonyms:ERGIC53,F5F8D;
Organism Homo sapiens (Human)

PRO ID PR:P49257
DAG View
PRO Name protein ERGIC-53 (human)
Definition A protein ERGIC-53 that is encoded in the genome of human.
Short Label hLMAN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49257 (LMAN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 O-Glycosylation GlyGen 33214551, 34725712, 33465208, ...29237092, 30397120
C18 Methylation IEDB 31844290
K49 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T276 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K302 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S364 O-Glycosylation GlyGen 33465208
S365 O-Glycosylation GlyGen 33214551, 34725712, 33465208, ...29237092, 30397120
K372 Ubiquitination PhosphoSitePlus
T385 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T385 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
S425 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S425 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
Y430 Phosphorylation PhosphoSitePlus
T432 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T433 O-Glycosylation GlyGen   PhosphoSitePlus 33214551, 30397120, 30459171, ...34725712, 25813380, 23584533, 33465208, 29237092
K440 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T276 R276 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K302 N302 Biomuta DOID:3571 / liver cancer [ cosmic ]
S364 F364 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K372 E372 Biomuta DOID:3571 / liver cancer [ cosmic ]
T385 N385 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T391 N391 Biomuta DOID:363 / uterine cancer [ icgc ]