iPTMnet Report for P49247 (RPIA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49247 / RPIA_HUMAN
Protein Name Ribose-5-phosphate isomerase
Gene Name Name: RPIA
Synonyms:RPI;
Organism Homo sapiens (Human)

PRO ID PR:P49247
DAG View
PRO Name ribose-5-phosphate isomerase (human)
Definition A ribose-5-phosphate isomerase that is encoded in the genome of human.
Short Label hRPIA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49247 (RPIA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y11 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
R46 Methylation PhosphoSitePlus
R52 Methylation PhosphoSitePlus   UniProt 24129315
S104 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S106 Phosphorylation PhosphoSitePlus   UniProt 23186163
K120 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K261 Acetylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y11 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S33 N33 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R52 S52 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K173 Q173 Biomuta DOID:1324 / lung cancer [ cosmic ]
K183 N183 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K211 E211 Biomuta DOID:1324 / lung cancer [ cosmic ]