iPTMnet Report P49137 MAPKAPK2

Protein Information

UniProt AC / UniProt ID	P49137 / MAPK2_HUMAN
Protein Name	MAP kinase-activated protein kinase 2
Gene Name	Name: MAPKAPK2
Organism	Homo sapiens (Human)

PRO ID	PR:P49137 DAG View
PRO Name	MAP kinase-activated protein kinase 2 (human)
Definition	A MAP kinase-activated protein kinase 2 that is encoded in the genome of human.
Short Label	hMAPKAPK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P49137 (MAPKAPK2) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S9	Phosphorylation	P28482 (MAPK1)	score3	neXtProt phospho.ELM PhosphoSitePlus UniProt	8846784
T25	Phosphorylation	Q16539 (MAPK14) , P28482 (MAPK1)	score3	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	8846784
K56	Ubiquitination		score1	PhosphoSitePlus
Y63	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
T66	Phosphorylation		score1	PhosphoSitePlus
S67	Phosphorylation		score1	PhosphoSitePlus
K84	Ubiquitination		score1	PhosphoSitePlus
K93	Ubiquitination		score1	PhosphoSitePlus
K100	Ubiquitination		score1	PhosphoSitePlus
C114	Methylation		score1	IEDB	31844290
S169	Phosphorylation		score1	IEDB	35494241
K188	Ubiquitination		score1	PhosphoSitePlus
K204	Ubiquitination		score1	PhosphoSitePlus
T206	Phosphorylation		score1	PhosphoSitePlus
K212	Ubiquitination		score1	PhosphoSitePlus
T214	Phosphorylation		score1	PhosphoSitePlus
T215	Phosphorylation		score1	PhosphoSitePlus
S219	Phosphorylation		score1	PhosphoSitePlus
T221	Phosphorylation		score1	PhosphoSitePlus
T222	Phosphorylation	P28482 (MAPK1) , P27361 (MAPK3) , Q16539 (MAPK14)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	8846784, 21575178, 7592979, ...32409685, 28506461, 19296855, 18669648, 32296033, 14499342
Y225	Phosphorylation		score1	PhosphoSitePlus
T226	Phosphorylation		score1	PhosphoSitePlus
S272	Phosphorylation	P28482 (MAPK1) , Q16539 (MAPK14)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	14499342, 8846784
K307	Ubiquitination		score1	PhosphoSitePlus
T317	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	9628873
S328	Phosphorylation		score1	PhosphoSitePlus
T329	Phosphorylation		score1	PhosphoSitePlus
T334	Phosphorylation	Q16539 (MAPK14) , P28482 (MAPK1) , P27361 (MAPK3)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	8652844, 32647362, 23186163, ...22028470, 8846784, 21575178, 7592979, 32409685, 16456544, 32296033, 24275569, 14499342, 24356814
T338	Phosphorylation	P28482 (MAPK1) , P49137 (MAPKAPK2)	score3	neXtProt phospho.ELM PhosphoSitePlus	8846784
S339	Phosphorylation		score1	PhosphoSitePlus
K353	Sumoylation		score1	PhosphoSitePlus
K353	Ubiquitination		score1	PhosphoSitePlus
Y367	Phosphorylation		score1	PhosphoSitePlus
K371	Ubiquitination		score1	PhosphoSitePlus
K374	Ubiquitination		score1	PhosphoSitePlus
K385	Ubiquitination		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T25	Phosphorylation	Q16539 (MAPK14)	score1	HPRD	8846784
Y63	Phosphorylation		score0	HPRD	17287340
T206	Phosphorylation	Q16539 (MAPK14)	score1	HPRD	7592979
T222	Phosphorylation	Q16539 (MAPK14)	score2	HPRD	18669648, 7592979, 8846784
S272	Phosphorylation	Q16539 (MAPK14)	score1	HPRD	8846784
T317	Phosphorylation	Q16539 (MAPK14)	score1	HPRD	7592979
T334	Phosphorylation	Q16539 (MAPK14)	score2	HPRD	8846784, 7592979
T338	Phosphorylation		score1	HPRD	8846784

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T25	Phosphorylation	Q16539 (MAPK14)	score1	HPRD	8846784
Y63	Phosphorylation		score0	HPRD	17287340
T206	Phosphorylation	Q16539 (MAPK14)	score1	HPRD	7592979
T222	Phosphorylation	Q16539 (MAPK14)	score2	HPRD	18669648, 7592979, 8846784
T317	Phosphorylation	Q16539 (MAPK14)	score1	HPRD	7592979
T334	Phosphorylation	Q16539 (MAPK14)	score2	HPRD	8846784, 7592979
T338	Phosphorylation		score1	HPRD	8846784
K353	Ubiquitination		score1	PhosphoSitePlus

P49137 (MAPKAPK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O00418 (EEF2K)	S377	score3	HPRD neXtProt phospho.ELM PhosphoSitePlus	12171600
O15511 (ARPC5)	S77	score4	HPRD neXtProt PhosphoSitePlus	12829704, 20068231
O75925 (PIAS1)	S522	score3	neXtProt PhosphoSitePlus Signor	23202365
O95453 (PARN)	S557	score3	neXtProt PhosphoSitePlus Signor	20932473
O95816 (BAG2)	S20	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	19651622, 15271996, 20068231
P04637 (TP53)	S20	score3	neXtProt PhosphoSitePlus	11896587
P04792 (HSPB1)	S15	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	19651622, 18691976, 18088087, ...18212344, 20230923, 1332886, 18767875, 19664994, 19007248, 16565220, 10383393, 19562805, 18669648, 11383510, 20626350, 20058876, 20166139, 20068231
P04792 (HSPB1)	S78	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	18212344, 12367505, 1332886, ...18767875, 20058876, 10383393, 20626350, 11383510, 20068231
P04792 (HSPB1)	S82	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	18578522, 16964243, 12367505, ...19562805, 10383393, 18707149, 18691976, 18212344, 19691289, 16565220, 18088087, 18767875, 20058876, 19007248, 19651622, 11383510, 1332886, 19664994, 19664995, 20626350, 18669648, 20166139, 19415658, 20068231, 17924679
P05783 (KRT18)	S53	score3	neXtProt PhosphoSitePlus	20724476
P07101-3 (TH)	S19	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	7901013, 12421349, 11359875, ...6150037
P07101 (TH)	S40	score4	HPRD phospho.ELM PhosphoSitePlus	7901013, 12421349
P07101-4 (TH)	S44	score2	PhosphoSitePlus	7901013
P07101-2 (TH)	S67	score2	PhosphoSitePlus	7901013
P07101 (TH)	S71	score4	neXtProt PhosphoSitePlus	7901013, 11359875
P07101-3 (TH)	S404	score2	PhosphoSitePlus	12421349
P08670 (VIM)	S39	score3	neXtProt phospho.ELM	12761892
P08670 (VIM)	S51	score3	neXtProt phospho.ELM	12761892
P08670 (VIM)	S56	score3	neXtProt phospho.ELM	12761892
P08670 (VIM)	S83	score3	neXtProt phospho.ELM	12761892
P09917 (ALOX5)	S272	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	11844797, 10779545
P11831 (SRF)	S85	score2	phospho.ELM	10318869
P11831 (SRF)	S103	score4	HPRD neXtProt PhosphoSitePlus Signor	10318869, 10753652, 12171911, ...8413226
P16220 (CREB1)	S119	score2	Signor	20626350, 17389598, 8887554
P16220-1 (CREB1)	S133	score1	HPRD	8887554
P17844 (DDX5)	S198	score3	neXtProt PhosphoSitePlus	23482664
P26651 (ZFP36)	S60	score2	neXtProt	14688255
P26651 (ZFP36)	S66	score2	neXtProt	14688255
P26651 (ZFP36)	S113	score2	neXtProt	14688255
P26651 (ZFP36)	S184	score2	neXtProt	14688255
P26651 (ZFP36)	S186	score2	neXtProt	14688255
P26651 (ZFP36)	T257	score2	neXtProt	14688255
P26651 (ZFP36)	T271	score2	neXtProt	14688255
P26651 (ZFP36)	S273	score2	neXtProt	14688255
P26651 (ZFP36)	S323	score2	neXtProt	14688255
P27815 (PDE4A)	S152	score3	neXtProt Signor	21323643
P30305 (CDC25B)	S169	score3	neXtProt PhosphoSitePlus	16861915
P30305 (CDC25B)	S323	score4	neXtProt phospho.ELM PhosphoSitePlus	16861915, 15629715
P30305 (CDC25B)	S353	score3	neXtProt PhosphoSitePlus	16861915
P30305 (CDC25B)	S375	score3	neXtProt PhosphoSitePlus	16861915
P30307 (CDC25C)	S216	score3	neXtProt PhosphoSitePlus	15629715
P31749 (AKT1)	S473	score3	neXtProt PhosphoSitePlus	8978681
P33241-2 (LSP1)	S142	score1	HPRD	8995217
P33241-2 (LSP1)	S190	score2	HPRD	19413330, 20166139, 8995217, ...20058876
P33241-1 (LSP1)	S204	score3	HPRD neXtProt phospho.ELM	8995217
P33241 (LSP1)	S252	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	8995217, 19413330, 17481585, ...20058876, 20166139
P35900 (KRT20)	S13	score3	neXtProt PhosphoSitePlus	20724476
P49137 (MAPKAPK2)	T338	score3	neXtProt phospho.ELM PhosphoSitePlus	8846784
P49815 (TSC2)	S1254	score3	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	12582162
P50549 (ETV1)	S191	score3	HPRD neXtProt	11551945
P50549-1 (ETV1)	S216	score3	HPRD neXtProt	11551945
P51812 (RPS6KA3)	S386	score2	neXtProt	17906627
P53350 (PLK1)	S326	score3	neXtProt PhosphoSitePlus Signor	18695677
P53350 (PLK1)	S383	score3	neXtProt PhosphoSitePlus	18695677
P53667 (LIMK1)	S323	score3	neXtProt PhosphoSitePlus Signor	16456544
P63104 (YWHAZ)	S58	score3	HPRD neXtProt PhosphoSitePlus Signor	12861023
Q00613 (HSF1)	S121	score3	neXtProt phospho.ELM PhosphoSitePlus	16278218
Q00987 (MDM2)	S157	score3	neXtProt PhosphoSitePlus	15688025
Q00987 (MDM2)	S166	score3	neXtProt PhosphoSitePlus Signor	15688025
Q01094 (E2F1)	S364	score2	neXtProt	22802261
Q07352 (ZFP36L1)	S54	score3	neXtProt PhosphoSitePlus Signor	18326031
Q07352 (ZFP36L1)	S92	score3	neXtProt PhosphoSitePlus Signor	18326031
Q07352 (ZFP36L1)	S203	score3	neXtProt PhosphoSitePlus Signor	18326031
Q07817 (BCL2L1)	S62	score3	neXtProt PhosphoSitePlus	22617334
Q13151 (HNRNPA0)	S84	score4	neXtProt PhosphoSitePlus	26602816, 12456657
Q13263 (TRIM28)	S473	score3	neXtProt PhosphoSitePlus	23740979
Q14134 (TRIM29)	S550	score2	PhosphoSitePlus	24469230
Q14134 (TRIM29)	S552	score2	PhosphoSitePlus	24469230
Q14457 (BECN1)	S90	score2	PhosphoSitePlus	25693418
Q15418 (RPS6KA1)	S380	score2	neXtProt	17906627
Q16875 (PFKFB3)	S461	score2	PhosphoSitePlus	23548149
Q6JBY9 (RCSD1)	S179	score3	neXtProt PhosphoSitePlus	15850461
Q6JBY9 (RCSD1)	S244	score3	neXtProt PhosphoSitePlus	15850461
Q7L5N7 (LPCAT2)	S34	score2	neXtProt	20663880
Q969V6 (MRTFA)	S312	score2	RLIMS-P+	27492266
Q969V6 (MRTFA)	S333	score2	RLIMS-P+	27492266
Q96J92 (WNK4)	S575	score2	PhosphoSitePlus	26732173
Q9H1R3 (MYLK2)	S151	score2	neXtProt	11795875
Q9NQC3-2 (RTN4)	S7	score2	neXtProt	16095439
Q9NQC3-2 (RTN4)	S107	score3	PhosphoSitePlus Signor	16095439
Q9NY61 (AATF)	T366	score3	neXtProt PhosphoSitePlus Signor	22909821
Q9UKV8 (AGO2)	S387	score4	neXtProt PhosphoSitePlus Signor	20626350, 18476811
Q9UPN4 (CEP131)	S47	score2	PhosphoSitePlus	26616734
Q9UPN4 (CEP131)	S78	score2	PhosphoSitePlus	26616734
Q9Y385 (UBE2J1)	S184	score3	RLIMS-P+ Signor	24020373

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000048330 (hMAPKAPK2/Phos:1)	pT222,pS272		PRO
	PR:000048331 (hMAPKAPK2/Phos:2)	pT222,pS272,pT334		PRO

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
T25	P25	Biomuta	DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
K56	N56	Biomuta	DOID:1319 / brain cancer [ cosmic ]
K56	E56	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T66	S66	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K84	T84	Biomuta	DOID:363 / uterine cancer [ icgc ]
K93	E93	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
S169	I169	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T215	P215	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T329	I329	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T338	S338	Biomuta	DOID:363 / uterine cancer [ cosmic ]
S339	N339	Biomuta	DOID:363 / uterine cancer [ icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P49137 (MAPKAPK2)

Protein Information

Interactive Sequence View

P49137 (MAPKAPK2) as Substrate

P49137 (MAPKAPK2) as PTM Enzyme

Proteoforms

PTM sites affected in variants