Protein Information

Cytoscape View


UniProt AC / UniProt ID P49137 / MAPK2_HUMAN
Protein Name MAP kinase-activated protein kinase 2
Gene Name Name: MAPKAPK2
Organism Homo sapiens (Human)

PRO ID PR:P49137
DAG View
PRO Name MAP kinase-activated protein kinase 2 (human)
Definition A MAP kinase-activated protein kinase 2 that is encoded in the genome of human.
Short Label hMAPKAPK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49137 (MAPKAPK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 8846784
T25 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 8846784
K56 Ubiquitination PhosphoSitePlus
Y63 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T66 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
T222 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , Q16539 (MAPK14) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23657501, 8846784, 32848211, ...21575178, 7592979, 32409685, 28506461, 19296855, 18669648, 32296033, 14499342
Y225 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
S272 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14499342, 8846784
K307 Ubiquitination PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus   RLIMS-P 9628873
S328 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
T334 Phosphorylation Q16539 (MAPK14) , P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8652844, 32647362, 23186163, ...22028470, 8846784, 32848211, 21575178, 7592979, 32409685, 16456544, 32296033, 24275569, 14499342, 24356814
T338 Phosphorylation P28482 (MAPK1) , P49137 (MAPKAPK2) neXtProt   phospho.ELM   PhosphoSitePlus 8846784
S339 Phosphorylation PhosphoSitePlus
K353 Sumoylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation Q16539 (MAPK14) HPRD 8846784
Y63 Phosphorylation HPRD 17287340
T206 Phosphorylation Q16539 (MAPK14) HPRD 7592979
T222 Phosphorylation Q16539 (MAPK14) HPRD 18669648, 7592979, 8846784
S272 Phosphorylation Q16539 (MAPK14) HPRD 8846784
T317 Phosphorylation Q16539 (MAPK14) HPRD 7592979
T334 Phosphorylation Q16539 (MAPK14) HPRD 8846784, 7592979
T338 Phosphorylation HPRD 8846784
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation Q16539 (MAPK14) HPRD 8846784
Y63 Phosphorylation HPRD 17287340
T206 Phosphorylation Q16539 (MAPK14) HPRD 7592979
T222 Phosphorylation Q16539 (MAPK14) HPRD 18669648, 7592979, 8846784
T317 Phosphorylation Q16539 (MAPK14) HPRD 7592979
T334 Phosphorylation Q16539 (MAPK14) HPRD 8846784, 7592979
T338 Phosphorylation HPRD 8846784
K353 Ubiquitination PhosphoSitePlus


P49137 (MAPKAPK2) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S377 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 12171600
O15511 (ARPC5) S77 HPRD   neXtProt   PhosphoSitePlus 12829704, 20068231
O75925 (PIAS1) S522 neXtProt   PhosphoSitePlus   Signor 23202365
O95453 (PARN) S557 neXtProt   PhosphoSitePlus   Signor 20932473
O95816 (BAG2) S20 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19651622, 15271996, 20068231
P04637 (TP53) S20 neXtProt   PhosphoSitePlus 11896587
P04792 (HSPB1) S15 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19651622, 18691976, 18088087, ...18212344, 20230923, 20626350, 18767875, 19664994, 19007248, 16565220, 10383393, 1332886, 18669648, 11383510, 20068231, 20058876, 20166139, 19562805
P04792 (HSPB1) S78 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18212344, 12367505, 1332886, ...18767875, 20058876, 10383393, 20626350, 11383510, 20068231
P04792 (HSPB1) S82 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18578522, 16964243, 12367505, ...19562805, 10383393, 18707149, 18691976, 18212344, 19691289, 16565220, 18088087, 18767875, 20058876, 19007248, 19651622, 11383510, 1332886, 19664994, 19664995, 20626350, 18669648, 20166139, 19415658, 20068231, 17924679
P05783 (KRT18) S53 neXtProt   PhosphoSitePlus 20724476
P07101-3 (TH) S19 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 7901013, 12421349, 11359875, ...6150037
P07101-3 (TH) S40 HPRD   phospho.ELM   PhosphoSitePlus 7901013, 12421349
P07101-4 (TH) S44 PhosphoSitePlus 7901013
P07101-2 (TH) S67 PhosphoSitePlus 7901013
P07101 (TH) S71 neXtProt   PhosphoSitePlus 7901013, 11359875
P07101-3 (TH) S404 PhosphoSitePlus 12421349
P08670 (VIM) S39 neXtProt   phospho.ELM 12761892
P08670 (VIM) S51 neXtProt   phospho.ELM 12761892
P08670 (VIM) S56 neXtProt   phospho.ELM 12761892
P08670 (VIM) S83 neXtProt   phospho.ELM 12761892
P09917 (ALOX5) S272 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11844797, 10779545
P11831 (SRF) S85 phospho.ELM 10318869
P11831 (SRF) S103 HPRD   neXtProt   PhosphoSitePlus   Signor 10318869, 10753652, 12171911, ...8413226
P16220 (CREB1) S119 Signor 20626350, 17389598, 8887554
P16220-1 (CREB1) S133 HPRD 8887554
P17844 (DDX5) S198 neXtProt   PhosphoSitePlus 23482664
P26651 (ZFP36) S60 neXtProt 14688255
P26651 (ZFP36) S66 neXtProt 14688255
P26651 (ZFP36) S113 neXtProt 14688255
P26651 (ZFP36) S184 neXtProt 14688255
P26651 (ZFP36) S186 neXtProt 14688255
P26651 (ZFP36) T257 neXtProt 14688255
P26651 (ZFP36) T271 neXtProt 14688255
P26651 (ZFP36) S273 neXtProt 14688255
P26651 (ZFP36) S323 neXtProt 14688255
P27815 (PDE4A) S152 neXtProt   Signor 21323643
P30305 (CDC25B) S169 neXtProt   PhosphoSitePlus 16861915
P30305 (CDC25B) S323 neXtProt   phospho.ELM   PhosphoSitePlus 16861915, 15629715
P30305 (CDC25B) S353 neXtProt   PhosphoSitePlus 16861915
P30305 (CDC25B) S375 neXtProt   PhosphoSitePlus 16861915
P30307 (CDC25C) S216 neXtProt   PhosphoSitePlus 15629715
P31749 (AKT1) S473 neXtProt   PhosphoSitePlus 8978681
P33241-2 (LSP1) S142 HPRD 8995217
P33241-2 (LSP1) S190 HPRD 19413330, 20166139, 8995217, ...20058876
P33241 (LSP1) S204 HPRD   neXtProt   phospho.ELM 8995217
P33241 (LSP1) S252 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19413330, 20166139, 8995217, ...17481585, 20058876
P35900 (KRT20) S13 neXtProt   PhosphoSitePlus 20724476
P49137 (MAPKAPK2) T338 neXtProt   phospho.ELM   PhosphoSitePlus 8846784
P49815 (TSC2) S1254 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12582162
P50549 (ETV1) S191 HPRD   neXtProt 11551945
P50549 (ETV1) S216 HPRD   neXtProt 11551945
P51812 (RPS6KA3) S386 neXtProt 17906627
P53350 (PLK1) S326 neXtProt   PhosphoSitePlus   Signor 18695677
P53350 (PLK1) S383 neXtProt   PhosphoSitePlus 18695677
P53667 (LIMK1) S323 neXtProt   PhosphoSitePlus   Signor 16456544
P63104 (YWHAZ) S58 HPRD   neXtProt   PhosphoSitePlus   Signor 12861023
Q00613 (HSF1) S121 neXtProt   phospho.ELM   PhosphoSitePlus 16278218
Q00987 (MDM2) S157 neXtProt   PhosphoSitePlus 15688025
Q00987 (MDM2) S166 neXtProt   PhosphoSitePlus   Signor 15688025
Q01094 (E2F1) S364 neXtProt 22802261
Q07352 (ZFP36L1) S54 neXtProt   PhosphoSitePlus   Signor 18326031
Q07352 (ZFP36L1) S92 neXtProt   PhosphoSitePlus   Signor 18326031
Q07352 (ZFP36L1) S203 neXtProt   PhosphoSitePlus   Signor 18326031
Q07817 (BCL2L1) S62 neXtProt   PhosphoSitePlus 22617334
Q13151 (HNRNPA0) S84 neXtProt   PhosphoSitePlus 26602816, 12456657
Q13263 (TRIM28) S473 neXtProt   PhosphoSitePlus 23740979
Q14134 (TRIM29) S550 PhosphoSitePlus 24469230
Q14134 (TRIM29) S552 PhosphoSitePlus 24469230
Q14457 (BECN1) S90 PhosphoSitePlus 25693418
Q15418 (RPS6KA1) S380 neXtProt 17906627
Q16875 (PFKFB3) S461 PhosphoSitePlus 23548149
Q6JBY9 (RCSD1) S179 neXtProt   PhosphoSitePlus 15850461
Q6JBY9 (RCSD1) S244 neXtProt   PhosphoSitePlus 15850461
Q7L5N7 (LPCAT2) S34 neXtProt 20663880
Q969V6 (MRTFA) S312 RLIMS-P+ 27492266
Q969V6 (MRTFA) S333 RLIMS-P+ 27492266
Q96J92 (WNK4) S575 PhosphoSitePlus 26732173
Q9H1R3 (MYLK2) S151 neXtProt 11795875
Q9NQC3-2 (RTN4) S7 neXtProt 16095439
Q9NQC3 (RTN4) S107 PhosphoSitePlus   Signor 16095439
Q9NY61 (AATF) T366 neXtProt   PhosphoSitePlus   Signor 22909821
Q9UKV8 (AGO2) S387 neXtProt   PhosphoSitePlus   Signor 20626350, 18476811
Q9UPN4 (CEP131) S47 PhosphoSitePlus 26616734
Q9UPN4 (CEP131) S78 PhosphoSitePlus 26616734
Q9Y385 (UBE2J1) S184 RLIMS-P+   Signor 24020373


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048330 (hMAPKAPK2/Phos:1) pT222,pS272 PRO
PR:000048331 (hMAPKAPK2/Phos:2) pT222,pS272,pT334 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P53667 (LIMK1) S323 P49137 (MAPKAPK2) unknown eFIP 16456544


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T25 P25 Biomuta DOID:3571 / liver cancer [ tcga ]
K56 T56 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K56 N56 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc ]
K56 E56 Biomuta DOID:1909 / melanoma [ cosmic ]
K84 T84 Biomuta DOID:363 / uterine cancer [ tcga ]
K100 N100 Biomuta DOID:3571 / liver cancer [ icgc ]
T215 P215 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
S219 F219 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T329 I329 Biomuta DOID:1324 / lung cancer [ cosmic ]
S339 N339 Biomuta DOID:363 / uterine cancer [ tcga ]