iPTMnet Report for P49116 (NR2C2)
Protein Information
| UniProt AC / UniProt ID | P49116 / NR2C2_HUMAN |
| Protein Name | Nuclear receptor subfamily 2 group C member 2 |
| Gene Name | Name: NR2C2 Synonyms:TAK1,TR4; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P49116 |
| PRO Name | nuclear receptor subfamily 2 group C member 2 (human) |
| Definition | A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human. |
| Short Label | hNR2C2 |
| Category | organism-gene |
DAG ViewP49116 (NR2C2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S19 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 16887930, 23186163, 19690332, ... | ||
| S46 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 19690332, 20068231 | ||
| S55 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 16887930 | ||
| K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S68 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 16887930, 23186163, 20068231 | ||
| S72 | O-Glycosylation | score1 | GlyGen | 31492838, 35289036, 35254053 | ||
| S73 | O-Glycosylation | score1 | GlyGen | 31492838, 35289036, 35254053 | ||
| S98 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| Y116 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S219 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
| T224 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T226 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| K231 | Acetylation | score1 | PhosphoSitePlus | |||
| K231 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T322 | O-Glycosylation | score1 | GlyGen | 31492838, 35289036, 35254053 | ||
| T322 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S328 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S330 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S351 | Phosphorylation | score3 | PhosphoSitePlus Signor | 21478464 | ||
| S351 | Phosphorylation | Q13131 (PRKAA1) | score1 | Signor | 21478464 | |
| T352 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S363 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K516 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K531 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S571 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S12 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T13 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S19 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
| S65 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S74 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S87 | Phosphorylation | score0 | HPRD | 18691976, 19007248, 20068231 | ||
| S117 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S238 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T243 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T245 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T371 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T13 | I13 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S46 | T46 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| S65 | T65 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| S68 | F68 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S68 | V68 | Biomuta | [ cosmic ] | |
| S87 | V87 | Biomuta | [ cosmic ] | |
| S87 | F87 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |
