Protein Information

Cytoscape View


UniProt AC / UniProt ID P49023 / PAXI_HUMAN
Protein Name Paxillin
Gene Name Name: PXN
Organism Homo sapiens (Human)

PRO ID PR:P49023
DAG View
PRO Name paxillin (human)
Definition A paxillin that is encoded in the genome of human.
Short Label hPXN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49023 (PXN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
T29 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation A0A059VC25 (FAK) , Q13882 (PTK6) , P00519 (ABL1) , Q05397 (PTK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12408869, 16624261, 7537852, ...24096476, 15107421, 18713649, 31101859, 11774284, 10823820, 25620625, 30755102, 27068537, 15572663, 16254239, 19304789, 15817476, 15688067, 26697169, 25826088, 26626996, 18392556
S32 Phosphorylation PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus 11695992, 16254239
S83 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation Q00535 (CDK5) , Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14970194, 22865050, 18669648, ...24275569, 19690332, 20068231
Y88 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus 18083107, 11695992, 16254239
S90 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 18220336
C108 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S109 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation A0A059VC25 (FAK) , P00519 (ABL1) , Q05397 (PTK2) , Q13882 (PTK6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24795566, 24096476, 28415719, ...7537852, 15107421, 7615549, 18713649, 31101859, 27402964, 11774284, 25620625, 30755102, 24885567, 27068537, 24396281, 15572663, 16254239, 19304789, 15817476, 18392556, 15592455, 15688067, 27913654, 24863063, 16094384, 26697169, 25826088, 18083107, 18669648, 26626996, 26447611
S119 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K123 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S126 Phosphorylation Q9UBE8 (NLK) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 12837288, 21406692, 23186163, ...18669648, 19840224, 19690332, 20068231
S130 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 12837288, 18669648, 16537926
T132 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S135 Phosphorylation PhosphoSitePlus
T136 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S137 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S140 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 24275569
S178 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   RLIMS-P 21779367, 22865050, 24193434, ...23890137, 18713649, 22750292, 29088796, 12853963
Y181 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16254239, 11774284
S188 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 18042622, 30745530
T249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus   UniProt 23128389
T251 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
S258 Phosphorylation Q13153 (PAK1) PhosphoSitePlus 23317503
S260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T263 Phosphorylation PhosphoSitePlus
S272 Phosphorylation Q13177 (PAK2) , O96013 (PAK4) , Q13153 (PAK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 31141452, 16717130, ...23317503, 31101859, 27068537, 20406887
S274 Phosphorylation Q13177 (PAK2) PhosphoSitePlus 23317503
K277 Ubiquitination PhosphoSitePlus
S302 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T318 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S320 Phosphorylation PhosphoSitePlus
S321 Phosphorylation phospho.ELM 18669648
S322 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S332 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S336 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus   UniProt 24275569
K540 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation Q05397 (PTK2) , Q13882 (PTK6) HPRD   PhosphoSitePlus 11337490, 15572663, 9658172
Y33 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation P41240 (CSK) HPRD   PhosphoSitePlus 11695992
S74 O-Glycosylation PhosphoSitePlus
S83 O-Glycosylation PhosphoSitePlus
S83 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   PhosphoSitePlus 18691976, 19664995, 20068231, ...20628053
S84 O-Glycosylation PhosphoSitePlus
S84 Phosphorylation HPRD   PhosphoSitePlus 17389395
S85 O-Glycosylation PhosphoSitePlus
S85 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 19664995, 19651622, ...17322306, 18669648, 18707149, 20068231
Y88 Phosphorylation P41240 (CSK) HPRD   phospho.ELM   PhosphoSitePlus 11695992, 17389395, 16212419, ...18707149
S90 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S103 Phosphorylation HPRD   PhosphoSitePlus 20068231
S106 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 16964243, 18220336, ...19664994, 19664995, 18669648, 19415658, 20068231, 18212344
S109 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation P06241 (FYN) , Q13882 (PTK6) , Q05397 (PTK2) HPRD   phospho.ELM   PhosphoSitePlus 15572663, 15870699, 18669648, ...17389395, 16212419, 18707149, 20068231, 9230116
S119 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S126 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20628053, ...20068231
S130 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20628053, ...20068231
T132 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231
S135 Phosphorylation HPRD 20068231
T136 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648
S137 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664994, 19664995
S143 Phosphorylation PhosphoSitePlus
S169 Phosphorylation HPRD 20068231
S170 Phosphorylation HPRD   PhosphoSitePlus 20068231
S178 Phosphorylation P45983 (MAPK8) HPRD   PhosphoSitePlus 12853963, 20068231
Y181 Phosphorylation HPRD   PhosphoSitePlus 11774284, 20068231
T186 Phosphorylation HPRD   PhosphoSitePlus 20068231
S188 Phosphorylation HPRD 9230116, 20068231, 9658172
K199 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
S219 Phosphorylation HPRD 20068231
S230 Phosphorylation HPRD   PhosphoSitePlus 20068231
T236 Phosphorylation HPRD   PhosphoSitePlus 20068231
S244 Phosphorylation Q00535 (CDK5) HPRD   PhosphoSitePlus 18042622, 20068231
T249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
S258 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T263 Phosphorylation PhosphoSitePlus
S272 Phosphorylation Q13153 (PAK1) , O96013 (PAK4) PhosphoSitePlus 16717130, 20406887
T284 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
S286 Phosphorylation PhosphoSitePlus
S287 Phosphorylation HPRD   PhosphoSitePlus 18669648
S288 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20058876, 20068231
S298 Phosphorylation HPRD   PhosphoSitePlus 18669648
S302 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
S380 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y434 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
T538 Phosphorylation Q05655 (PRKCD) neXtProt 20388733
Site PTM Type PTM Enzyme Score Source PMID
Y31 Phosphorylation PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
S106 Phosphorylation phospho.ELM 18220336
Y118 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048972 (hPXN/Phos:2) pY31,pY118 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49023 (PXN) S178 Q05397 (PTK2) increased_association eFIP 21779367
Phosphorylation P49023 (PXN) S244 Q05397 (PTK2) decreased_association eFIP 18042622
Phosphorylation Q05397 (PTK2) Y577 P49023 (PXN) inhibited_association eFIP 18171471


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y31 * Biomuta DOID:3571 / liver cancer [ icgc ]
S130 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:5041 / esophageal cancer [ tcga ]
T136 M136 Biomuta DOID:1909 / melanoma [ cosmic ]
S188 N188 Biomuta DOID:363 / uterine cancer [ tcga ]
T249 N249 Biomuta DOID:3571 / liver cancer [ icgc ]
S274 L274 Biomuta DOID:363 / uterine cancer [ tcga ]
S303 R303 Biomuta DOID:10283 / prostate cancer [ cosmic ]