iPTMnet Report for P49006 (MARCKSL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49006 / MRP_HUMAN
Protein Name MARCKS-related protein
Gene Name Name: MARCKSL1
Synonyms:MLP,MRP;
Organism Homo sapiens (Human)

PRO ID PR:P49006
DAG View
PRO Name MARCKS-related protein (human)
Definition A MARCKS-related protein that is encoded in the genome of human.
Short Label hMARCKSL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49006 (MARCKSL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805
T14 Phosphorylation PhosphoSitePlus   UniProt 23186163
S22 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...17287340, 17081983, 18767875, 19664994, 19664995, 18452278, 19651622, 17322306, 18669648, 19690332, 23186163, 19415658, 20068231
K25 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S41 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 23186163, ...19690332
K43 Ubiquitination PhosphoSitePlus
S48 Phosphorylation HPRD   PhosphoSitePlus 19413330, 15345747, 19664994
T54 Phosphorylation HPRD   PhosphoSitePlus 19664994
T61 Phosphorylation PhosphoSitePlus
S71 Phosphorylation Q13535 (ATR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18077418, 17525332, 15345747, ...19690332
K83 Ubiquitination PhosphoSitePlus
T85 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 17322306, ...18669648, 17287340, 20068231
K88 Ubiquitination PhosphoSitePlus
S93 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...20068231
K95 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S101 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17287340, ...18212344, 19651622, 27920218, 18669648, 23186163, 20068231
S104 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17287340, ...18212344, 18767875, 20058876, 35494241, 19664995, 19651622, 17322306, 18669648, 24275569, 18707149, 20166139, 23186163, 30784271, 20068231, 17924679
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S116 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S117 Phosphorylation HPRD   PhosphoSitePlus 19413330
S119 Phosphorylation HPRD   PhosphoSitePlus 19413330
S120 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 15345747, 24275569
T122 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17287340
C134 S-Nitrosylation dbSNO 26338901
S135 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15345747, 17287340
K144 Ubiquitination PhosphoSitePlus
T148 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18669648, 24275569, 20166139, 15345747
S151 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163
S162 Phosphorylation HPRD   PhosphoSitePlus 19413330, 15345747, 19664995
S165 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...18452278, 15345747
T174 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17287340, 18452278
S177 Phosphorylation HPRD   PhosphoSitePlus 19413330
T178 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17287340, 19664995, ...18452278, 18669648, 24275569, 15345747
S180 Phosphorylation HPRD   PhosphoSitePlus 19413330, 15345747, 18452278
S184 Phosphorylation HPRD   PhosphoSitePlus 19413330
S190 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 F41 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K83 T83 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S101 R101 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S104 P104 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S117 Y117 Biomuta DOID:1319 / brain cancer [ icgc ]
S117 F117 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S119 C119 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C134 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S180 L180 Biomuta DOID:3571 / liver cancer [ cosmic ]
S184 I184 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]