iPTMnet Report for P49005 (POLD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49005 / DPOD2_HUMAN
Protein Name DNA polymerase delta subunit 2
Gene Name Name: POLD2
Organism Homo sapiens (Human)

PRO ID PR:P49005
DAG View
PRO Name DNA polymerase delta subunit 2 (human)
Definition A DNA polymerase delta subunit 2 that is encoded in the genome of human.
Short Label hPOLD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49005 (POLD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
T12 Phosphorylation PhosphoSitePlus
S15 O-Glycosylation GlyGen 34019948, 28510447, 36580660, ...30059200
S15 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S18 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y263 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
C314 Methylation IEDB 31844290
K389 Ubiquitination PhosphoSitePlus
C398 Methylation IEDB 31844290
K413 Ubiquitination PhosphoSitePlus
C447 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y50 C50 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S75 N75 Biomuta [ cosmic ]