Protein Information

Cytoscape View


UniProt AC / UniProt ID P48764 / SL9A3_HUMAN
Protein Name Sodium/hydrogen exchanger 3
Gene Name Name: SLC9A3
Synonyms:NHE3;
Organism Homo sapiens (Human)

PRO ID PR:P48764
DAG View
PRO Name sodium/hydrogen exchanger 3 (human)
Definition A sodium/hydrogen exchanger 3 that is encoded in the genome of human.
Short Label hSLC9A3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48764 (SLC9A3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y396 Phosphorylation PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
T564 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
T641 Phosphorylation PhosphoSitePlus
S663 Phosphorylation P51812 (RPS6KA3) , O00141 (SGK1) neXtProt   PhosphoSitePlus   RLIMS-P 15888551, 25855080
K682 Acetylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y502 F502 Biomuta DOID:1324 / lung cancer [ cosmic ]
S545 R545 Biomuta DOID:363 / uterine cancer [ tcga ]
S545 G545 Biomuta DOID:363 / uterine cancer [ tcga ]
T641 M641 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S663 Y663 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]