iPTMnet Report P48736 PIK3CG

Protein Information

UniProt AC / UniProt ID	P48736 / PK3CG_HUMAN
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Gene Name	Name: PIK3CG
Organism	Homo sapiens (Human)

PRO ID	PR:P48736 DAG View
PRO Name	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (human)
Definition	A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform that is encoded in the genome of human.
Short Label	hPIK3CG
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P48736 (PIK3CG) as Substrate

P48736

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K7	Ubiquitination		score1	PhosphoSitePlus
K103	Ubiquitination		score1	PhosphoSitePlus
S227	Phosphorylation		score1	PhosphoSitePlus
T228	Phosphorylation		score1	PhosphoSitePlus
T229	Phosphorylation		score1	PhosphoSitePlus
S230	Phosphorylation		score1	PhosphoSitePlus
T232	Phosphorylation		score1	PhosphoSitePlus
T250	Phosphorylation		score1	PhosphoSitePlus
K288	Ubiquitination		score1	PhosphoSitePlus
K444	Ubiquitination		score1	PhosphoSitePlus
K501	Ubiquitination		score1	PhosphoSitePlus
K553	Ubiquitination		score1	PhosphoSitePlus
S582	Phosphorylation		score3	neXtProt PhosphoSitePlus	23824069
S582	Phosphorylation	P05771 (PRKCB)	score3	neXtProt PhosphoSitePlus	23824069
K597	Ubiquitination		score1	PhosphoSitePlus
K606	Ubiquitination		score1	PhosphoSitePlus
T607	Phosphorylation		score1	PhosphoSitePlus
S620	Phosphorylation		score1	PhosphoSitePlus
T627	Phosphorylation		score1	PhosphoSitePlus
S636	Phosphorylation		score1	PhosphoSitePlus
S650	Phosphorylation		score1	PhosphoSitePlus
T746	Phosphorylation		score1	PhosphoSitePlus
K750	Ubiquitination		score1	PhosphoSitePlus
K756	Ubiquitination		score1	PhosphoSitePlus
Y757	Phosphorylation		score1	PhosphoSitePlus
S765	Phosphorylation		score1	IEDB	35494241
K768	Ubiquitination		score1	PhosphoSitePlus
K770	Ubiquitination		score1	PhosphoSitePlus
K792	Ubiquitination		score1	PhosphoSitePlus
S853	Phosphorylation		score1	PhosphoSitePlus
K903	Ubiquitination		score1	PhosphoSitePlus
K912	Ubiquitination		score1	PhosphoSitePlus
S974	Phosphorylation		score1	PhosphoSitePlus
K1000	Acetylation		score1	PhosphoSitePlus
T1024	Phosphorylation		score3	neXtProt PhosphoSitePlus	21474070
T1024	Phosphorylation	P17612 (PRKACA)	score2	neXtProt	21474070
S1101	Phosphorylation		score4	HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt	12661022, 12502714
S1101	Phosphorylation	P48736 (PIK3CG)	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	12661022, 12502714

P48736 (PIK3CG) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P07951-2 (TPM2)	S61	score1	HPRD	16094730
P48736 (PIK3CG)	S1101	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	12661022, 12502714
Q01105-2 (SET)	S9	score2	PhosphoSitePlus	21419339
Q01105-2 (SET)	S93	score2	PhosphoSitePlus	21419339

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K7	E7	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K103	N103	Biomuta	DOID:263 / kidney cancer [ cosmic ]
S227	I227	Biomuta	DOID:4362 / cervical cancer [ icgc ]
T228	I228	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T228	N228	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T229	S229	Biomuta	DOID:1319 / brain cancer [ cosmic ]
T229	N229	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
T232	N232	Biomuta	DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K444	*	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S620	I620	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S636	P636	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S650	I650	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K756	N756	Biomuta	DOID:363 / uterine cancer [ icgc ]
S765	P765	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K768	N768	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K768	R768	Biomuta	[ cosmic ]
K770	N770	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S974	N974	Biomuta	DOID:1319 / brain cancer [ icgc ]
S974	T974	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
T1024	K1024	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S1101	P1101	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S1101	L1101	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P48736 (PIK3CG)

Protein Information

Interactive Sequence View

P48736 (PIK3CG) as Substrate

P48736 (PIK3CG) as PTM Enzyme

PTM sites affected in variants