Protein Information

Cytoscape View

UniProt AC / UniProt ID P48735 / IDHP_HUMAN
Protein Name Isocitrate dehydrogenase [NADP], mitochondrial precursor
Gene Name Name: IDH2
Organism Homo sapiens (Human)

PRO ID PR:P48735
DAG View
PRO Name isocitrate dehydrogenase [NADP], mitochondrial (human)
Definition An isocitrate dehydrogenase [NADP], mitochondrial that is encoded in the genome of human.
Short Label hIDH2nadp
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P48735 (IDH2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K48 Acetylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus   UniProt 19608861
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K106 Acetylation PhosphoSitePlus   UniProt 19608861
K106 Ubiquitination PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
K127 Methylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus   UniProt 19608861
K155 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus   UniProt 19608861
K166 Ubiquitination PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus   UniProt 19608861
K180 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K242 Acetylation PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
K256 Acetylation PhosphoSitePlus   UniProt 19608861
K256 Ubiquitination PhosphoSitePlus
K263 Acetylation PhosphoSitePlus   UniProt 19608861
K263 Ubiquitination PhosphoSitePlus
K272 Acetylation PhosphoSitePlus   UniProt 19608861
K272 Ubiquitination PhosphoSitePlus
K275 Acetylation PhosphoSitePlus   UniProt 19608861
K275 Ubiquitination PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
K282 Acetylation PhosphoSitePlus   UniProt 19608861
K282 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
C308 S-Nitrosylation dbSNO 26338901
T350 Phosphorylation PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K413 Acetylation PhosphoSitePlus   UniProt 22416140
K413 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K442 Acetylation PhosphoSitePlus   UniProt 19608861
K442 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S108 Phosphorylation HPRD 20058876
T115 Phosphorylation HPRD 20058876

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 N48 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K133 R133 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K155 N155 Biomuta DOID:363 / uterine cancer [ tcga ]
R188 W188 Biomuta DOID:1324 / lung cancer [ cosmic ]
K280 N280 Biomuta DOID:363 / uterine cancer [ tcga ]
K282 T282 Biomuta DOID:363 / uterine cancer [ tcga ]
T350 N350 Biomuta DOID:3571 / liver cancer [ icgc ]
K442 R442 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]