iPTMnet Report for P48730 (CSNK1D)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48730 / KC1D_HUMAN
Protein Name Casein kinase I isoform delta
Gene Name Name: CSNK1D
Synonyms:HCKID;
Organism Homo sapiens (Human)

PRO ID PR:P48730
DAG View
PRO Name casein kinase I isoform delta (human)
Definition A casein kinase I isoform delta that is encoded in the genome of human.
Short Label hCSNK1D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48730 (CSNK1D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K242 Acetylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T329 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S331 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17192257
R335 Methylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
T347 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T349 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S350 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T355 Phosphorylation PhosphoSitePlus
S356 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S361 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S370 Phosphorylation P31749 (AKT1) , P49760 (CLK2) , P17612 (PRKACA) neXtProt 17594292
R375 Methylation PhosphoSitePlus
S382 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17192257
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 18220336
S384 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T387 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus   UniProt 23186163
S411 Phosphorylation PhosphoSitePlus   UniProt 19369195
Site PTM Type PTM Enzyme Score Source PMID
S234 Phosphorylation HPRD 20068231
S328 Phosphorylation HPRD 18691976, 18669648
T329 Phosphorylation HPRD 18691976, 18669648
S331 Phosphorylation HPRD 18691976, 18669648, 17192257
T344 Phosphorylation HPRD 18691976
T347 Phosphorylation HPRD 18691976, 18669648
T349 Phosphorylation HPRD 18691976, 18669648
S350 Phosphorylation HPRD 18691976, 18669648, 17081983
T352 Phosphorylation HPRD 18691976
T355 Phosphorylation HPRD 18691976
S356 Phosphorylation HPRD 18691976, 18669648
S361 Phosphorylation HPRD 18691976, 18669648
S382 Phosphorylation HPRD 18691976, 18669648, 19664995, ...20068231, 17192257
S383 Phosphorylation HPRD 18691976, 19664995
S384 Phosphorylation HPRD 18691976, 18669648
T387 Phosphorylation HPRD 18691976
S406 Phosphorylation HPRD 18691976
S407 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S234 Phosphorylation HPRD 20068231
S328 Phosphorylation HPRD 18691976, 18669648
T329 Phosphorylation HPRD 18691976, 18669648
S331 Phosphorylation HPRD 18691976, 18669648, 17192257
T344 Phosphorylation HPRD 18691976
T347 Phosphorylation HPRD 18691976, 18669648
T349 Phosphorylation HPRD 18691976, 18669648
S350 Phosphorylation HPRD 18691976, 18669648, 17081983
T352 Phosphorylation HPRD 18691976
T355 Phosphorylation HPRD 18691976
S356 Phosphorylation HPRD 18691976, 18669648
S361 Phosphorylation HPRD 18691976, 18669648
S382 Phosphorylation HPRD 18691976, 18669648, 19664995, ...20068231, 17192257
S383 Phosphorylation HPRD   phospho.ELM 18691976, 19664995, 18220336
S384 Phosphorylation HPRD 18691976, 18669648
T387 Phosphorylation HPRD 18691976
S396 Phosphorylation HPRD   PhosphoSitePlus 18691976
T397 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S398 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S401 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231


P48730 (CSNK1D) as PTM Enzyme



Substrate Site Score Source PMID
O14641 (DVL2) S143 PhosphoSitePlus   Signor 22609948
O14641 (DVL2) T224 PhosphoSitePlus   Signor 22609948
O15055 (PER2) S662 PhosphoSitePlus 21324900
O15055 (PER2) S665 PhosphoSitePlus 21324900
O15055 (PER2) S668 PhosphoSitePlus 21324900
O15055-1 (PER2) S977 HPRD 16097765
O15169 (AXIN1) S46 Signor 12000790
O43312 (MTSS1) S322 PhosphoSitePlus 24318128
P02810 (PRH2) S24 Signor 10684652
P04637 (TP53) S9 PhosphoSitePlus 10930428
P04637-1 (TP53) T18 HPRD   PhosphoSitePlus   Signor 10734067, 10606744
P04637 (TP53) S20 PhosphoSitePlus   Signor 10606744, 18669630, 10734067, ...20041275
P10636-8 (MAPT) S202 PhosphoSitePlus 14761950
P10636-8 (MAPT) T205 PhosphoSitePlus 14761950
P10636-8 (MAPT) S396 PhosphoSitePlus   Signor 14761950
P10636-8 (MAPT) S404 PhosphoSitePlus 14761950
P10636 (MAPT) S519 Signor 14761950
P10636 (MAPT) T522 Signor 14761950
P10636 (MAPT) S721 Signor 14761950
P12830 (CDH1) S844 PhosphoSitePlus 17353278
P17302 (GJA1) S325 HPRD 12270943
P17302 (GJA1) S328 HPRD 12270943
P17302 (GJA1) S330 HPRD 12270943, 18578522
P25054 (APC) S1504 PhosphoSitePlus 17910481
P25054 (APC) S1505 PhosphoSitePlus 17910481
P25054 (APC) S1507 PhosphoSitePlus 17910481
P25054 (APC) S1510 PhosphoSitePlus 17910481
P27707 (DCK) S11 PhosphoSitePlus 20637175
P27707 (DCK) S15 PhosphoSitePlus 20637175
P27707 (DCK) T72 PhosphoSitePlus 20637175
P27707 (DCK) S74 PhosphoSitePlus 20637175
P30291 (WEE1) S212 PhosphoSitePlus 24817118
P35222 (CTNNB1) S45 HPRD   PhosphoSitePlus   Signor 11955436, 12000790
P37840-1 (SNCA) S129 HPRD 10852916, 10617630
P43629 (KIR3DL1) S385 PhosphoSitePlus   Signor 17911614
P43629 (KIR3DL1) S388 PhosphoSitePlus   Signor 17911614
P46937-2 (YAP1) S384 PhosphoSitePlus 20048001
P46937 (YAP1) S400 Signor 23431053, 24715453
P46937 (YAP1) S403 Signor 23431053, 24715453
P49810-3 (PSEN2) S7 HPRD 8972483
P49810-1 (PSEN2) S9 HPRD 8972483
P49810-1 (PSEN2) S19 HPRD 8972483, 20068231
P49810-1 (PSEN2) S327 HPRD   PhosphoSitePlus 9990034, 9558331
P49810-3 (PSEN2) S329 HPRD 9990034, 9558331
P49810-1 (PSEN2) S330 HPRD   PhosphoSitePlus 9990034, 9558331
P49810-3 (PSEN2) S334 HPRD 9558331
P49810-1 (PSEN2) S335 HPRD 9558331
P56817-4 (BACE1) S429 HPRD 11278841
P56817-3 (BACE1) S454 HPRD 11278841
P56817-2 (BACE1) S473 HPRD 11278841
P56817 (BACE1) S498 HPRD   PhosphoSitePlus   Signor 11278841
Q00535-1 (CDK5) S159 HPRD 10500146
Q00987 (MDM2) S118 PhosphoSitePlus   Signor 20708156
Q00987 (MDM2) S121 PhosphoSitePlus   Signor 20708156
Q00987 (MDM2) S166 PhosphoSitePlus 20708156
Q00987 (MDM2) S172 PhosphoSitePlus 20708156
Q00987 (MDM2) S176 PhosphoSitePlus 20708156
Q00987 (MDM2) S220 PhosphoSitePlus 20708156
Q00987 (MDM2) S229 PhosphoSitePlus 20708156
Q00987 (MDM2) S240 PhosphoSitePlus 20708156
Q00987 (MDM2) S246 Signor 20708156
Q00987 (MDM2) S253 PhosphoSitePlus   Signor 20708156, 12167711
Q00987 (MDM2) S260 PhosphoSitePlus 20708156
Q00987 (MDM2) S262 PhosphoSitePlus   Signor 20708156, 12167711
Q00987 (MDM2) S269 PhosphoSitePlus   Signor 20708156, 12167711
Q00987 (MDM2) T279 PhosphoSitePlus 20708156
Q00987 (MDM2) S290 PhosphoSitePlus 20708156
Q00987 (MDM2) S342 PhosphoSitePlus 20708156
Q00987 (MDM2) S350 PhosphoSitePlus 20708156
Q00987 (MDM2) T351 PhosphoSitePlus 20708156
Q00987 (MDM2) T365 PhosphoSitePlus 20708156
Q00987 (MDM2) S373 PhosphoSitePlus 20708156
Q00987 (MDM2) S386 PhosphoSitePlus 20708156
Q00987 (MDM2) T419 PhosphoSitePlus 20708156
Q16665 (HIF1A) S247 PhosphoSitePlus   Signor 20699359
Q6U7Q0 (ZNF322) S396 Signor 28581525
Q96T88 (UHRF1) S95 PhosphoSitePlus   Signor 23297342
Q9BZL6 (PRKD2) S244 PhosphoSitePlus 17962809
Q9GZV5 (WWTR1) S314 Signor 24715453
Q9Y6Q9 (NCOA3) S601 PhosphoSitePlus   Signor 19339517


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S15 P48730 (CSNK1D) unknown eFIP 35752942


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K122 N122 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S331 F331 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R335 L335 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T337 M337 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T344 P344 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R375 C375 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S383 L383 Biomuta [ cosmic ]
S396 F396 Biomuta DOID:4159 / skin cancer [ cosmic ]
S398 P398 Biomuta DOID:3571 / liver cancer [ cosmic ]
S411 F411 Biomuta [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]