iPTMnet Report for P48668 (KRT6C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48668 / K2C6C_HUMAN
Protein Name Keratin, type II cytoskeletal 6C
Gene Name Name: KRT6C
Synonyms:KRT6E;
Organism Homo sapiens (Human)

PRO ID PR:P48668
DAG View
PRO Name keratin, type II cytoskeletal 6C (human)
Definition A keratin, type II cytoskeletal 6C that is encoded in the genome of human.
Short Label hKRT6C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48668 (KRT6C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
R16 Methylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
R24 Methylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
R59 Methylation PhosphoSitePlus
S60 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 9054461
Y62 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S71 Phosphorylation HPRD   PhosphoSitePlus 18452278
S76 Phosphorylation HPRD   PhosphoSitePlus 18452278
S80 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation HPRD   PhosphoSitePlus 18452278
S85 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Methylation PhosphoSitePlus
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K194 Methylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K252 Methylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
K259 Methylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S348 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
R475 Methylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
K550 Methylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
T552 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 G3 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S5 F5 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R16 W16 Biomuta DOID:363 / uterine cancer [ icgc ]
R16 Q16 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ icgc ]
S31 F31 Biomuta DOID:4159 / skin cancer [ cosmic ]
S37 F37 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S71 F71 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S85 I85 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S176 F176 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y341 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T358 I358 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K426 T426 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S546 N546 Biomuta DOID:1324 / lung cancer [ cosmic ]
S557 F557 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S561 N561 Biomuta DOID:4159 / skin cancer [ cosmic ]