Protein Information

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UniProt AC / UniProt ID P48634 / PRC2A_HUMAN
Protein Name Protein PRRC2A
Gene Name Name: PRRC2A
Synonyms:BAT2,G2;
Organism Homo sapiens (Human)

PRO ID PR:P48634
DAG View
PRO Name protein PRRC2A (human)
Definition A large proline-rich protein BAT2 that is encoded in the genome of human.
Short Label hPRRC2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48634 (PRRC2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y17 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus   UniProt 23186163
S19 Phosphorylation PhosphoSitePlus   UniProt 23186163
T25 Phosphorylation PhosphoSitePlus
Y26 Phosphorylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus   UniProt 19608861
S30 Phosphorylation PhosphoSitePlus   UniProt 23186163
K35 Acetylation PhosphoSitePlus
R41 Methylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
R55 Methylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S114 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S119 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus   UniProt 23186163
S159 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   UniProt 23186163
S204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
T206 Phosphorylation PhosphoSitePlus
R232 Methylation PhosphoSitePlus
R247 Methylation PhosphoSitePlus
R272 Methylation PhosphoSitePlus   UniProt 24129315
R281 Methylation PhosphoSitePlus
R284 Methylation PhosphoSitePlus
R289 Methylation PhosphoSitePlus
R296 Methylation PhosphoSitePlus   UniProt 24129315
S305 Phosphorylation PhosphoSitePlus
Y335 Phosphorylation PhosphoSitePlus
S342 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...18669648, 23186163
S350 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...18669648, 23186163
S363 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S365 Phosphorylation PhosphoSitePlus
S380 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 19690332, 20068231
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T387 Phosphorylation PhosphoSitePlus
S456 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340, ...19690332
S457 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S458 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
K502 Acetylation PhosphoSitePlus
T517 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
T609 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
T610 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 22028470, 15302935, ...19690332
T610 Phosphorylation P28482 (MAPK1) neXtProt 22028470
S631 Phosphorylation PhosphoSitePlus
Y636 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
R710 Methylation PhosphoSitePlus
R722 Methylation PhosphoSitePlus
Y729 Phosphorylation PhosphoSitePlus
R738 Methylation PhosphoSitePlus
S759 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S761 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...17287340, 19690332
S764 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163
S765 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S766 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R771 Methylation PhosphoSitePlus
T782 Phosphorylation PhosphoSitePlus
T799 Phosphorylation PhosphoSitePlus
S808 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S823 Phosphorylation PhosphoSitePlus
T825 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T878 Phosphorylation PhosphoSitePlus
T894 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S920 Phosphorylation PhosphoSitePlus
T922 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus   UniProt 23186163
S933 Phosphorylation PhosphoSitePlus
T975 Phosphorylation PhosphoSitePlus
T997 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1004 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16083285, 23186163, ...22028470
S1004 Phosphorylation P28482 (MAPK1) neXtProt 22028470
Y1013 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1015 Phosphorylation PhosphoSitePlus
R1024 Methylation PhosphoSitePlus
R1026 Methylation PhosphoSitePlus
R1028 Methylation PhosphoSitePlus
R1034 Methylation PhosphoSitePlus
R1036 Methylation PhosphoSitePlus
R1039 Methylation PhosphoSitePlus
S1056 Phosphorylation PhosphoSitePlus
R1066 Methylation PhosphoSitePlus
R1080 Methylation PhosphoSitePlus
R1082 Methylation PhosphoSitePlus
T1083 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1085 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T1087 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1089 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S1092 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y1094 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T1108 Phosphorylation PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T1112 Phosphorylation PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus
S1120 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1126 Phosphorylation PhosphoSitePlus
S1147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R1152 Methylation PhosphoSitePlus
R1156 Methylation PhosphoSitePlus
R1159 Methylation PhosphoSitePlus
R1164 Methylation PhosphoSitePlus
R1169 Methylation PhosphoSitePlus
K1196 Acetylation PhosphoSitePlus   UniProt 19608861
S1219 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 22028470, 18088087, ...17081983, 18220336, 15302935, 18669648, 24275569, 23186163, 20068231
S1219 Phosphorylation P28482 (MAPK1) neXtProt 22028470
R1223 Methylation PhosphoSitePlus
S1306 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1310 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1314 Phosphorylation PhosphoSitePlus
T1323 Phosphorylation PhosphoSitePlus
S1325 Phosphorylation PhosphoSitePlus
S1328 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1347 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
T1353 Phosphorylation PhosphoSitePlus   UniProt 20068231
R1370 Methylation PhosphoSitePlus
R1376 Methylation PhosphoSitePlus
K1378 Methylation PhosphoSitePlus
R1383 Methylation PhosphoSitePlus
S1384 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1386 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1387 Phosphorylation PhosphoSitePlus
R1398 Methylation PhosphoSitePlus
S1410 Phosphorylation PhosphoSitePlus
R1422 Methylation PhosphoSitePlus
R1427 Methylation PhosphoSitePlus
S1432 Phosphorylation PhosphoSitePlus
S1435 Phosphorylation PhosphoSitePlus
S1489 Phosphorylation PhosphoSitePlus
K1500 Ubiquitination PhosphoSitePlus
Y1518 Phosphorylation PhosphoSitePlus
S1525 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1546 Phosphorylation PhosphoSitePlus
S1554 Phosphorylation PhosphoSitePlus
T1607 Phosphorylation PhosphoSitePlus
S1671 Phosphorylation PhosphoSitePlus
R1686 Methylation PhosphoSitePlus
S1690 Phosphorylation PhosphoSitePlus
S1691 Phosphorylation PhosphoSitePlus
R1708 Methylation PhosphoSitePlus
R1743 Methylation PhosphoSitePlus
R1772 Methylation PhosphoSitePlus
S1778 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1790 O-Glycosylation GlyGen 23301498, 20305658, 28657654, ...32119511
S1796 O-Glycosylation GlyGen 23301498, 20305658, 28657654, ...32119511
K1814 Ubiquitination PhosphoSitePlus
R1865 Methylation PhosphoSitePlus
Y1874 Phosphorylation PhosphoSitePlus
R1875 Methylation PhosphoSitePlus
S2036 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2056 Ubiquitination PhosphoSitePlus
Y2061 Phosphorylation PhosphoSitePlus
K2063 Ubiquitination PhosphoSitePlus
T2076 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2082 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2084 Phosphorylation PhosphoSitePlus
S2088 Phosphorylation PhosphoSitePlus
R2089 Methylation PhosphoSitePlus
K2091 Ubiquitination PhosphoSitePlus
T2093 Phosphorylation PhosphoSitePlus
Y2109 Phosphorylation PhosphoSitePlus
S2113 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T2128 Phosphorylation PhosphoSitePlus
S2137 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation HPRD 18212344
S114 Phosphorylation HPRD 17287340
S204 Phosphorylation HPRD 17287340
S342 Phosphorylation HPRD 17287340, 19691289, 18452278, ...19651622, 18669648, 20068231
S350 Phosphorylation HPRD 17322306, 19651622, 18669648, ...17287340, 20068231
S380 Phosphorylation HPRD 18669648, 15302935, 19691289, ...20068231
S383 Phosphorylation HPRD 18669648, 19664995
S456 Phosphorylation HPRD 20166139, 18669648, 17287340
S457 Phosphorylation HPRD 18669648
T517 Phosphorylation HPRD 18669648, 17287340
T609 Phosphorylation HPRD 18669648, 19664995
T610 Phosphorylation HPRD 19413330, 18669648, 15302935, ...19664995, 20068231
S759 Phosphorylation HPRD 19651622, 18669648, 19691289, ...20068231
S761 Phosphorylation HPRD 19651622, 17287340, 18669648, ...19664994, 20068231
S764 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
S765 Phosphorylation HPRD 19651622, 18669648, 20068231
S766 Phosphorylation HPRD 18669648
T782 Phosphorylation HPRD 20068231
S808 Phosphorylation HPRD 18669648, 20068231
T825 Phosphorylation HPRD 18669648
T997 Phosphorylation HPRD 18669648
S1004 Phosphorylation HPRD 18669648, 20068231
S1014 Phosphorylation HPRD 18669648, 16083285
T1083 Phosphorylation HPRD 18669648, 17081983
S1085 Phosphorylation HPRD 19651622, 18669648, 17081983
T1087 Phosphorylation HPRD 19651622, 18669648
S1089 Phosphorylation HPRD 19651622, 18669648, 19664994, ...17081983, 18452278
S1092 Phosphorylation HPRD 17322306, 19651622, 18669648, ...19664994, 18452278
Y1094 Phosphorylation HPRD 18669648
S1106 Phosphorylation HPRD 17081983
T1108 Phosphorylation HPRD 17081983
S1110 Phosphorylation HPRD 17081983, 20068231, 18452278
T1112 Phosphorylation HPRD 17081983, 18452278
S1147 Phosphorylation HPRD 19413330, 18669648, 20068231
S1219 Phosphorylation HPRD 19413330, 18491316, 18088087, ...15302935, 20058876, 19664995, 19691289, 19651622, 18669648, 19415658, 20068231
S1306 Phosphorylation HPRD 18669648, 20068231, 18452278
S1310 Phosphorylation HPRD 18669648
T1347 Phosphorylation HPRD 18669648, 19664995, 20068231
T1353 Phosphorylation HPRD 20068231
S1432 Phosphorylation HPRD 17322306
T1764 Phosphorylation HPRD 20068231
S1778 Phosphorylation HPRD 20068231
S2073 Phosphorylation HPRD 20068231
S2113 Phosphorylation HPRD 20068231
T2128 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S342 Phosphorylation phospho.ELM 18669648
S350 Phosphorylation phospho.ELM 18669648
S380 Phosphorylation phospho.ELM 18669648
S383 Phosphorylation phospho.ELM 18669648
S749 Phosphorylation PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus
S1080 Phosphorylation PhosphoSitePlus
S1086 Phosphorylation PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
T1340 Phosphorylation PhosphoSitePlus 18847512
T1340 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 L19 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K49 N49 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R55 H55 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S166 F166 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R232 Q232 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
R247 C247 Biomuta DOID:1612 / breast cancer [ icgc ]
R272 Q272 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R284 H284 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R289 Q289 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R289 P289 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
S305 C305 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S380 F380 Biomuta DOID:1909 / melanoma [ tcga ]
S458 P458 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
R710 Q710 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R722 L722 Biomuta DOID:1324 / lung cancer [ tcga ]
R722 Q722 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S761 I761 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S766 T766 Biomuta DOID:1909 / melanoma [ tcga ]
S823 N823 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R1024 P1024 Biomuta DOID:363 / uterine cancer [ tcga ]
R1036 S1036 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R1039 Q1039 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
R1039 W1039 Biomuta DOID:1115 / sarcoma [ tcga ]
R1080 Q1080 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1324 / lung cancer [ tcga ]
R1082 H1082 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:3963 / thyroid carcinoma [ tcga ]
T1087 I1087 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1087 A1087 Biomuta DOID:1909 / melanoma [ cosmic ]
S1106 L1106 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R1152 C1152 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R1152 H1152 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1219 Y1219 Biomuta DOID:1324 / lung cancer [ tcga ]
S1219 P1219 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
R1223 H1223 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S1306 F1306 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R1370 C1370 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
R1383 W1383 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1386 L1386 Biomuta DOID:2531 / hematologic cancer [ tcga ]
T1607 P1607 Biomuta DOID:363 / uterine cancer [ tcga ]
R1686 M1686 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1691 L1691 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1796 * Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K1814 N1814 Biomuta DOID:363 / uterine cancer [ tcga ]
K1814 T1814 Biomuta DOID:1324 / lung cancer [ tcga ]
R1865 H1865 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R2089 S2089 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R2089 C2089 Biomuta DOID:363 / uterine cancer [ tcga ]