iPTMnet Report for P48556 (PSMD8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48556 / PSMD8_HUMAN
Protein Name 26S proteasome non-ATPase regulatory subunit 8
Gene Name Name: PSMD8
Organism Homo sapiens (Human)

PRO ID PR:P48556
DAG View
PRO Name 26S proteasome non-ATPase regulatory subunit 8 (human)
Definition A 26S proteasome non-ATPase regulatory subunit 8 that is encoded in the genome of human.
Short Label hPSMD8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48556 (PSMD8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus   UniProt 23186163
K111 Ubiquitination PhosphoSitePlus
C112 Methylation IEDB 31844290
K120 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S155 O-Glycosylation GlyGen 33214551, 34725712, 36580660, ...31373491, 34019948
K159 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
T295 Phosphorylation IEDB   PhosphoSitePlus 32387766
K297 Acetylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
Y315 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K99 M99 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K111 E111 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K135 N135 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K159 N159 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K298 R298 Biomuta DOID:2531 / hematologic cancer [ cosmic ]