iPTMnet Report for P48549 (KCNJ3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48549 / KCNJ3_HUMAN
Protein Name G protein-activated inward rectifier potassium channel 1
Gene Name Name: KCNJ3
Synonyms:GIRK1;
Organism Homo sapiens (Human)

PRO ID PR:P48549
DAG View
PRO Name G protein-activated inward rectifier potassium channel 1 (human)
Definition A G protein-activated inward rectifier potassium channel 1 that is encoded in the genome of human.
Short Label hKCNJ3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48549 (KCNJ3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
N119 N-Glycosylation GlyGen   UniProt 10889209
S369 Phosphorylation PhosphoSitePlus
S385 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 19151997
S401 Phosphorylation PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation HPRD 17924679
T73 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S69 W69 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S69 L69 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S385 Y385 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S401 C401 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S420 I420 Biomuta DOID:1612 / breast cancer [ cosmic ]
S420 N420 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K457 N457 Biomuta DOID:1324 / lung cancer [ cosmic ]