iPTMnet Report for P48449 (LSS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48449 / LSS_HUMAN
Protein Name Lanosterol synthase
Gene Name Name: LSS
Synonyms:OSC;
Organism Homo sapiens (Human)

PRO ID PR:P48449
DAG View
PRO Name lanosterol synthase (human)
Definition A lanosterol synthase that is encoded in the genome of human.
Short Label hLSS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48449 (LSS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 22814378
R10 Methylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
C29 Methylation IEDB 31844290
K61 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
Y158 Phosphorylation PhosphoSitePlus
K194 Acetylation PhosphoSitePlus
C243 Methylation IEDB 31844290
S249 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
Y320 Phosphorylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
Y368 Phosphorylation PhosphoSitePlus
C410 Methylation IEDB 31844290
K432 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
C598 Methylation IEDB 31844290
C616 Methylation IEDB 31844290
C653 Methylation IEDB 31844290
C676 Methylation IEDB 31844290
K680 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
C700 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S334 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R10 L10 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R10 Q10 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K15 M15 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K15 N15 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K61 N61 Biomuta DOID:363 / uterine cancer [ icgc ]
K65 T65 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y368 C368 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K439 N439 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]