Protein Information

Cytoscape View


UniProt AC / UniProt ID P48436 / SOX9_HUMAN
Protein Name Transcription factor SOX-9
Gene Name Name: SOX9
Organism Homo sapiens (Human)

PRO ID PR:P48436
DAG View
PRO Name transcription factor SOX-9 (human)
Definition A transcription factor SOX-9 that is encoded in the genome of human.
Short Label hSOX9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48436 (SOX9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
S64 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10805756, 27571710, 15889150
K68 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S181 Phosphorylation P17612 (PRKACA) , Q13237 (PRKG2) , Q13464 (ROCK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10805756, 33985544, 15466490, ...19470758, 15889150, 20039424, 27571710, 11120880
T196 Phosphorylation PhosphoSitePlus   RLIMS-P 33173725
S199 Phosphorylation PhosphoSitePlus
S211 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 10805756, 27929080
S214 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus   RLIMS-P 33173725, 27625374, 27566146
T239 Phosphorylation PhosphoSitePlus
T240 Phosphorylation RLIMS-P 27566146
K249 Ubiquitination PhosphoSitePlus
K253 Acetylation PhosphoSitePlus
K398 Acetylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S64 R64 Biomuta DOID:1324 / lung cancer [ cosmic ]
K68 E68 Biomuta DOID:1909 / melanoma [ cosmic ]
K141 N141 Biomuta DOID:4362 / cervical cancer [ tcga ]
K141 E141 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ cosmic ]
Y172 H172 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S199 P199 Biomuta DOID:263 / kidney cancer [ tcga ]
S214 P214 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
S414 * Biomuta DOID:1909 / melanoma [ cosmic ]