iPTMnet Report for P48426 (PIP4K2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48426 / PI42A_HUMAN
Protein Name Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Gene Name Name: PIP4K2A
Synonyms:PI5P4KA,PIP5K2,PIP5K2A;
Organism Homo sapiens (Human)

PRO ID PR:P48426
DAG View
PRO Name phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (human)
Definition A phosphatidylinositol 5-phosphate 4-kinase type-2 alpha that is encoded in the genome of human.
Short Label hPIP4K2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48426 (PIP4K2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 19369195, 22223895, ...20068231
T3 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S10 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 20068231, ...19369195
K15 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K89 Acetylation PhosphoSitePlus   UniProt 19608861
K89 Methylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K91 Methylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K145 Acetylation PhosphoSitePlus   UniProt 19608861
K145 Ubiquitination PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
S304 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 10508590
S304 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 10508590
K367 Acetylation PhosphoSitePlus
K375 Methylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T376 Phosphorylation neXtProt   PhosphoSitePlus   Signor 16563698
T376 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   Signor 16563698
K395 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 18691976
S9 Phosphorylation HPRD 18691976
S14 Phosphorylation HPRD 18691976, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K81 R81 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K89 N89 Biomuta DOID:363 / uterine cancer [ icgc ]
Y93 H93 Biomuta DOID:11934 / head and neck cancer [ icgc ]
K244 Q244 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K244 T244 Biomuta DOID:1319 / brain cancer [ icgc ]
K244 N244 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K375 E375 Biomuta DOID:3565 / meningioma [ cosmic ]