iPTMnet Report for P48357 (LEPR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48357 / LEPR_HUMAN
Protein Name Leptin receptor precursor
Gene Name Name: LEPR
Synonyms:DB,OBR;
Organism Homo sapiens (Human)

PRO ID PR:P48357
DAG View
PRO Name leptin receptor (human)
Definition A leptin receptor that is encoded in the genome of human.
Short Label hLEPR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48357 (LEPR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N23 N-Glycosylation GlyGen   UniProt 9786864
S36 Phosphorylation PhosphoSitePlus
N41 N-Glycosylation GlyGen   UniProt 9786864
S42 Phosphorylation PhosphoSitePlus
N56 N-Glycosylation GlyGen   UniProt 9786864
N73 N-Glycosylation GlyGen   UniProt 29391424, 9786864
N81 N-Glycosylation GlyGen   UniProt 9786864
N98 N-Glycosylation GlyGen   UniProt 29391424, 9786864
S172 Phosphorylation PhosphoSitePlus
N187 N-Glycosylation GlyGen   UniProt 9786864
N206 N-Glycosylation GlyGen   UniProt 29391424, 9786864
T208 Phosphorylation PhosphoSitePlus
N276 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29391424, ...19159218, 9786864
N347 N-Glycosylation GlyGen   UniProt 29391424, 9786864
N397 N-Glycosylation GlyGen   UniProt 19159218, 9786864
N516 N-Glycosylation GlyGen   UniProt 16335952, 9786864
Y621 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
N624 N-Glycosylation GlyGen   UniProt 29391424, 9786864
S626 Phosphorylation PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
N659 N-Glycosylation GlyGen   UniProt 29391424, 9786864
N670 N-Glycosylation GlyGen 29391424
N688 N-Glycosylation GlyGen   UniProt 9786864
N697 N-Glycosylation GlyGen   UniProt 9786864
N728 N-Glycosylation GlyGen   UniProt 9786864
N750 N-Glycosylation GlyGen   UniProt 9786864
Y795 Phosphorylation PhosphoSitePlus
Y796 Phosphorylation PhosphoSitePlus
K879 Ubiquitination PhosphoSitePlus
S882 Phosphorylation PhosphoSitePlus   UniProt 24275569
K891 Ubiquitination PhosphoSitePlus
T937 Phosphorylation PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus
T946 Phosphorylation PhosphoSitePlus
Y986 Phosphorylation IntAct   PhosphoSitePlus   Signor 9600917, 11342028, 11018044
Y986 Phosphorylation O60674 (JAK2) Signor 11018044
Y1079 Phosphorylation PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
Y1141 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 14625304, 11018044
Y1141 Phosphorylation O60674 (JAK2) Signor 11018044
Site PTM Type PTM Enzyme Score Source PMID
T208 Phosphorylation HPRD 20058876
Y986 Phosphorylation HPRD 10449753
Y1141 Phosphorylation HPRD 10449753
Site PTM Type PTM Enzyme Score Source PMID
T208 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
T208 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 F36 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
N81 S81 Biomuta DOID:4159 / skin cancer [ cosmic ]
S172 * Biomuta DOID:363 / uterine cancer [ cosmic ]
N187 H187 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N347 D347 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N347 H347 Biomuta DOID:3571 / liver cancer [ cosmic ]
N624 D624 Biomuta DOID:4159 / skin cancer [ cosmic ]
K879 T879 Biomuta DOID:4159 / skin cancer [ cosmic ]
S882 P882 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K891 N891 Biomuta DOID:1324 / lung cancer [ cosmic ]
S944 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1090 I1090 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1090 R1090 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1141 C1141 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]