iPTMnet Report for P48200 (IREB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48200 / IREB2_HUMAN
Protein Name Iron-responsive element-binding protein 2
Gene Name Name: IREB2
Organism Homo sapiens (Human)

PRO ID PR:P48200
DAG View
PRO Name iron-responsive element-binding protein 2 (human)
Definition An iron-responsive element-binding protein 2 that is encoded in the genome of human.
Short Label hIREB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48200 (IREB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S157 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18574241, 18669648
K160 Acetylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
R175 Methylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
C178 S-Nitrosylation dbSNO 16479012, 22178444, 15688001, ...14673166
S180 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
Y541 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
C720 Methylation IEDB 31844290
K726 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
R774 Methylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K868 Ubiquitination PhosphoSitePlus
K877 Ubiquitination PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
T913 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S157 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K5 E5 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K23 N23 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K70 T70 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S157 F157 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K160 E160 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R175 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R175 Q175 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S177 F177 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K240 N240 Biomuta DOID:1324 / lung cancer [ cosmic ]
K402 N402 Biomuta DOID:5158 / pleural cancer [ cosmic ]
K413 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S425 T425 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K485 N485 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
K611 N611 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K726 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K848 Q848 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K848 I848 Biomuta DOID:4159 / skin cancer [ cosmic ]
K860 T860 Biomuta DOID:3571 / liver cancer [ cosmic ]
K877 T877 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]