iPTMnet Report for P48163 (ME1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48163 / MAOX_HUMAN
Protein Name NADP-dependent malic enzyme
Gene Name Name: ME1
Organism Homo sapiens (Human)

PRO ID PR:P48163
DAG View
PRO Name NADP-dependent malic enzyme (human)
Definition An NADP-dependent malic enzyme that is encoded in the genome of human.
Short Label hME1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48163 (ME1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
Y16 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T103 Phosphorylation RLIMS-P 34965422
Y113 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K569 Sumoylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K26 Q26 Biomuta DOID:4159 / skin cancer [ cosmic ]
K60 Q60 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S67 F67 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S92 C92 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K337 N337 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K512 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K525 N525 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]