iPTMnet Report for P48147 (PREP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48147 / PPCE_HUMAN
Protein Name Prolyl endopeptidase
Gene Name Name: PREP
Synonyms:PEP;
Organism Homo sapiens (Human)

PRO ID PR:P48147
DAG View
PRO Name prolyl endopeptidase (human)
Definition A prolyl endopeptidase that is encoded in the genome of human.
Short Label hPREP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48147 (PREP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
Y19 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus   UniProt 19608861
K162 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
R643 Methylation PhosphoSitePlus
Y658 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S241 Y241 Biomuta DOID:3571 / liver cancer [ icgc ]
Y246 F246 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
R643 S643 Biomuta DOID:3571 / liver cancer [ icgc ]
R643 C643 Biomuta DOID:10534 / stomach cancer [ tcga ]
S667 N667 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]