Protein Information

Cytoscape View


UniProt AC / UniProt ID P48025 / KSYK_MOUSE
Protein Name Tyrosine-protein kinase SYK
Gene Name Name: Syk
Synonyms:ptk72,Sykb;
Organism Mus musculus (Mouse)

PRO ID PR:P48025
DAG View
PRO Name tyrosine-protein kinase SYK (mouse)
Definition A tyrosine-protein kinase SYK that is encoded in the genome of mouse.
Short Label mSYK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48025 (Syk) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y14 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation P25911 (Lyn) , P48025 (Syk) phospho.ELM   PhosphoSitePlus 9820500, 18689684
S201 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus   UniProt 21183079
S279 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S310 Phosphorylation UniProt 17947660
S313 Phosphorylation UniProt 17947660
Y317 Phosphorylation P25911 (Lyn) , P48025 (Syk) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17947660, 9820500, 28722316, ...9857068, 31873727, 12077122
T320 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation P25911 (Lyn) , P48025 (Syk) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11672534, 17947660, 16410013, ...9820500, 28716125, 8657103, 31089414, 12077122
Y346 Phosphorylation P48025 (Syk) , P25911 (Lyn) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17947660, 31249969, 16410013, ...9820500, 8657103, 31089414, 12077122
Y358 Phosphorylation P48025 (Syk) phospho.ELM   PhosphoSitePlus 8657103
S373 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
Y501 Phosphorylation PhosphoSitePlus
Y519 Phosphorylation P48025 (Syk) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11672534, 17947660, 9820500, ...8657103, 26891724
Y520 Phosphorylation P48025 (Syk) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11672534, 17947660, 9820500, ...8657103, 26891724
Y540 Phosphorylation PhosphoSitePlus   UniProt 17947660
K565 Acetylation PhosphoSitePlus
Y623 Phosphorylation PhosphoSitePlus   UniProt 17947660
Y624 Phosphorylation PhosphoSitePlus   UniProt 17947660
Y625 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y317 Phosphorylation PRO 15536084
Y342 Phosphorylation PRO 15536084, 27609517
Y346 Phosphorylation PRO 15536084, 27609517
Y519 Phosphorylation PRO 27609517
Y520 Phosphorylation PRO 27609517


P48025 (Syk) as PTM Enzyme



Substrate Site Score Source PMID
P20444 (Prkca) Y658 phospho.ELM   PhosphoSitePlus 12881490
P22682 (Cbl) Y737 RLIMS-P+ 20851882
P48025 (Syk) Y130 phospho.ELM   PhosphoSitePlus 18689684, 9820500
P48025 (Syk) Y317 PhosphoSitePlus 9820500, 12077122
P48025 (Syk) Y342 phospho.ELM   PhosphoSitePlus 9820500, 12077122, 8657103
P48025 (Syk) Y346 phospho.ELM   PhosphoSitePlus 9820500, 12077122, 8657103
P48025 (Syk) Y358 phospho.ELM 8657103
P48025 (Syk) Y519 phospho.ELM   PhosphoSitePlus   UniProt 9820500, 8657103, 11672534
P48025 (Syk) Y520 phospho.ELM   PhosphoSitePlus 9820500, 8657103
P68369 (Tuba1a) Y432 phospho.ELM 8566014
P70218 (Map4k1) Y379 PhosphoSitePlus 11514608
Q03267 (Ikzf1) S357 PhosphoSitePlus 23071339
Q03267 (Ikzf1) S360 PhosphoSitePlus 23071339
Q06649 (Sh3bp2) Y174 PhosphoSitePlus 12709437
Q06649 (Sh3bp2) Y183 PhosphoSitePlus 12709437
Q06649 (Sh3bp2) Y446 PhosphoSitePlus 12709437
Q6A028 (Swap70) Y517 PhosphoSitePlus 21123826


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025834 (mSYK/iso:1/Phos:1) pY317,pY342,pY346 PRO 15536084
PR:000049791 (mSYK/iso:1/Phos:2) pY342 PRO 27609517
PR:000049793 (mSYK/iso:1/Phos:3) pY346 PRO 27609517
PR:000049795 (mSYK/iso:1/Phos:4) pY342,pY346 PRO 27609517
PR:000049796 (mSYK/iso:1/Phos:5) pY342,pY346,pY519,pY520 PRO 27609517
PR:000049800 (mSYK/iso:1/Phos:6) pY342,pY346 PRO 27609517


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P48025 (Syk) Y342 P14234 (Fgr) unknown eFIP 11672534
Phosphorylation P48025 (Syk) Y346 P08487 (PLCG1) unknown eFIP 16410013


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025834 (mSYK/iso:1/Phos:1) Interaction PR:P09769 (hFGR) PRO 15536084
PR:000025834 (mSYK/iso:1/Phos:1) Interaction PR:P27986 (hPIK3R1) PRO 15536084