iPTMnet Report for P47974 (ZFP36L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P47974 / TISD_HUMAN
Protein Name mRNA decay activator protein ZFP36L2
Gene Name Name: ZFP36L2
Synonyms:ERF2;
Organism Homo sapiens (Human)

PRO ID PR:P47974
DAG View
PRO Name mRNA decay activator protein ZFP36L2 (human)
Definition An mRNA decay activator protein ZFP36L2 that is encoded in the genome of human.
Short Label hZFP36L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P47974 (ZFP36L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation PhosphoSitePlus
C16 Methylation IEDB 31844290
K20 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S57 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 27869121
S59 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S70 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
T110 O-Glycosylation GlyGen 23301498, 36240223
K115 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S125 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692
S131 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
C168 Methylation IEDB 31844290
K169 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
R211 Methylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus   UniProt 23186163
S257 Phosphorylation PhosphoSitePlus
S259 Phosphorylation IEDB   PhosphoSitePlus 27869121
S261 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S438 Phosphorylation IEDB   PhosphoSitePlus 32387766
S440 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S490 Phosphorylation HPRD   IEDB   PhosphoSitePlus   UniProt 25106868, 27869121, 33936100, ...20068231
S492 Phosphorylation PhosphoSitePlus   UniProt 25106868


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C16 G16 Biomuta DOID:4159 / skin cancer [ cosmic ]
C16 Y16 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
C16 R16 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S21 F21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S46 L46 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T96 A96 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y98 D98 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T100 A100 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K102 Q102 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S123 W123 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S123 L123 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K155 R155 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K155 N155 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C168 Y168 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
C168 W168 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K169 E169 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K193 N193 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T199 I199 Biomuta DOID:4159 / skin cancer [ cosmic ]
T202 A202 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T202 N202 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y208 D208 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R211 H211 Biomuta DOID:263 / kidney cancer [ cosmic ]
R211 C211 Biomuta DOID:1612 / breast cancer [ icgc ]
S259 G259 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T284 A284 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S438 F438 Biomuta [ cosmic ]
S438 P438 Biomuta DOID:263 / kidney cancer [ icgc ]