Protein Information

Cytoscape View


UniProt AC / UniProt ID P47736 / RPGP1_HUMAN
Protein Name Rap1 GTPase-activating protein 1
Gene Name Name: RAP1GAP
Synonyms:KIAA0474,RAP1GA1;
Organism Homo sapiens (Human)

PRO ID PR:P47736
DAG View
PRO Name Rap1 GTPase-activating protein 1 (human)
Definition A Rap1 GTPase-activating protein 1 that is encoded in the genome of human.
Short Label hRAP1GAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P47736 (RAP1GAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y27 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K378 Acetylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 19218462
S460 Phosphorylation PhosphoSitePlus
S484 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 25329897, 23186163, ...1406653
T486 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S490 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P 1406653
S495 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 19218462, 1406653, ...18669648, 24275569
S515 Phosphorylation PhosphoSitePlus   UniProt 23186163
T522 Phosphorylation PhosphoSitePlus
S525 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 25329897, 14660640
S541 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S484 Phosphorylation P06493 (CDK1) HPRD 18767875, 1406653, 18669648, ...20068231
T486 Phosphorylation HPRD 18669648, 20068231
S490 Phosphorylation P17612 (PRKACA) HPRD 1406653
S499 Phosphorylation P17612 (PRKACA) HPRD 1406653, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S493 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S437 N437 Biomuta DOID:363 / uterine cancer [ tcga ]
S437 R437 Biomuta DOID:3571 / liver cancer [ icgc ]
T486 K486 Biomuta DOID:3571 / liver cancer [ icgc ]
S490 L490 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S495 C495 Biomuta DOID:1612 / breast cancer [ cosmic ]
T522 N522 Biomuta DOID:3571 / liver cancer [ icgc ]
S542 F542 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T547 K547 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]