iPTMnet Report for P47712 (PLA2G4A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P47712 / PA24A_HUMAN
Protein Name Cytosolic phospholipase A2
Gene Name Name: PLA2G4A
Synonyms:CPLA2,PLA2G4;
Organism Homo sapiens (Human)

PRO ID PR:P47712
DAG View
PRO Name cytosolic phospholipase A2 (human)
Definition A cytosolic phospholipase A2 that is encoded in the genome of human.
Short Label hPLA2G4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P47712 (PLA2G4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 33247192
Y7 Phosphorylation PhosphoSitePlus
T21 Phosphorylation HPRD   PhosphoSitePlus 20068231
T31 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
C151 S-Nitrosylation dbSNO 22178444, 18029351
K155 Ubiquitination PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S178 Phosphorylation HPRD   PhosphoSitePlus 20068231
S183 Phosphorylation PhosphoSitePlus
S228 Phosphorylation phospho.ELM   PhosphoSitePlus 15539760
K257 Ubiquitination PhosphoSitePlus
T268 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 18767875, ...17322306, 18669648, 20068231
K271 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus   RLIMS-P 32559461
S412 Phosphorylation PhosphoSitePlus
S431 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S434 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087, 17081983, 18212344
S435 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17081983, 18767875, ...18452278, 19651622, 23186163, 20068231, 18212344
S437 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17322306, 21406692, 23186163, ...17081983, 18767875, 8636128, 19651622, 18669648, 18088087, 18452278, 9468497, 20068231, 18212344
S441 Phosphorylation HPRD   PhosphoSitePlus 17081983
T447 Phosphorylation PhosphoSitePlus
S454 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 9468497, 8636128
Y456 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S505 Phosphorylation P27361 (MAPK3) , Q16539 (MAPK14) , P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19401382, 19162293, 8381049, ...25893499, 26416244, 9468497, 27977772, 16375935, 8777586, 19625654, 7766652, 9115999, 12885780, 10978317, 20667012, 19718435, 8706669, 24693448, 16301670, 8910365, 17725579, 12444032, 20211985, 10491174, 32559461, 20044029, 17081983, 19778898, 10567216, 28993924, 35408744, 8636128, 27819025, 19843712, 20068231
S508 Phosphorylation HPRD 20068231
T512 Phosphorylation HPRD 17081983
S515 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 27977772, 11479288, 17081983
Y535 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K541 Sumoylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
Y718 Phosphorylation PhosphoSitePlus
S724 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18767875, 18669648, 20068231
S727 Phosphorylation Q8IW41 (MAPKAPK5) , O75582 (RPS6KA5) , Q9BUB5 (MKNK1) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 16964243, 19664994, ...18065419, 8636128, 18669648, 12885780, 10978317, 10491174, 9468497, 20068231, 18212344
S729 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18767875, ...15302935, 17322306, 18669648, 20068231, 18212344
K741 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048794 (hPLA2G4A/Phos:1) pS505,pS727 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y7 N7 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T21 M21 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K32 N32 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K155 N155 Biomuta DOID:1324 / lung cancer [ cosmic ]
K171 R171 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S178 I178 Biomuta DOID:1324 / lung cancer [ cosmic ]
S183 C183 Biomuta DOID:4159 / skin cancer [ cosmic ]
K257 R257 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K281 E281 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K316 M316 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y359 C359 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K371 R371 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T376 K376 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T376 S376 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T376 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S434 G434 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S515 F515 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K606 N606 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S727 C727 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K741 Q741 Biomuta DOID:10534 / stomach cancer [ cosmic ]