iPTMnet Report for P46934 (NEDD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46934 / NEDD4_HUMAN
Protein Name E3 ubiquitin-protein ligase NEDD4
Gene Name Name: NEDD4
Synonyms:KIAA0093,NEDD4-1,RPF1;ORFNames:PIG53;
Organism Homo sapiens (Human)

PRO ID PR:P46934
DAG View
PRO Name E3 ubiquitin-protein ligase NEDD4 (human)
Definition An E3 ubiquitin-protein ligase NEDD4 that is encoded in the genome of human.
Short Label hNEDD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46934 (NEDD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
K63 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
S738 O-Glycosylation GlyGen 30379171, 31373491
S742 O-Glycosylation GlyGen 31373491
S742 Phosphorylation PhosphoSitePlus   UniProt 23186163
S743 Phosphorylation PhosphoSitePlus
S747 Phosphorylation IEDB   PhosphoSitePlus   UniProt 30784271, 18669648, 19690332
Y785 Phosphorylation PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
K1146 Ubiquitination PhosphoSitePlus
K1279 Ubiquitination UniProt 32101753
Site PTM Type PTM Enzyme Score Source PMID
S598 Phosphorylation PhosphoSitePlus
S666 Phosphorylation HPRD 18669648
S667 Phosphorylation HPRD 18669648, 20068231
S670 Phosphorylation HPRD 18669648, 20068231
S675 Phosphorylation HPRD 19651622, 18669648, 20058876
Y679 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y43 Phosphorylation PhosphoSitePlus
T57 Phosphorylation HPRD 20068231
S58 Phosphorylation HPRD 20068231
K71 Ubiquitination PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S319 Phosphorylation HPRD 18669648
S320 Phosphorylation HPRD 18669648, 20068231
S323 Phosphorylation HPRD 18669648, 20068231
S324 Phosphorylation PhosphoSitePlus
S328 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20058876
Y332 Phosphorylation HPRD   PhosphoSitePlus 18669648
Y366 Phosphorylation PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K535 Acetylation PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus
Y585 Phosphorylation PhosphoSitePlus
Y647 Phosphorylation PhosphoSitePlus
K667 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K71 E71 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y647 H647 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S888 A888 Biomuta DOID:1324 / lung cancer [ icgc ]
K1146 T1146 Biomuta DOID:363 / uterine cancer [ icgc ]