iPTMnet Report for P46736 (BRCC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46736 / BRCC3_HUMAN
Protein Name Lys-63-specific deubiquitinase BRCC36
Gene Name Name: BRCC3
Synonyms:BRCC36,C6.1A,CXorf53;
Organism Homo sapiens (Human)

PRO ID PR:P46736
DAG View
PRO Name lys-63-specific deubiquitinase BRCC36 (human)
Definition A lys-63-specific deubiquitinase BRCC36 that is encoded in the genome of human.
Short Label hBRCC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46736 (BRCC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Ubiquitination PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus   UniProt 23186163
K261 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S231 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K65 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S206 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y55 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T55 S55 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
K180 N180 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K181 N181 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S258 L258 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S258 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]