iPTMnet Report for P46734 (MAP2K3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46734 / MP2K3_HUMAN
Protein Name Dual specificity mitogen-activated protein kinase kinase 3
Gene Name Name: MAP2K3
Synonyms:MEK3,MKK3,PRKMK3,SKK2;
Organism Homo sapiens (Human)

PRO ID PR:P46734
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 3 (human)
Definition A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human.
Short Label hMAP2K3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46734 (MAP2K3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 20068231
S3 Phosphorylation PhosphoSitePlus   UniProt 20068231
S15 Phosphorylation PhosphoSitePlus   UniProt 20068231
S28 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K192 Sumoylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
S218 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 7839144, 9786855, 8622669, ...19804365, 9003778, 19920149, 9162092, 11279118
S218 Phosphorylation P41279 (MAP3K8) PhosphoSitePlus 19804365
S218 Phosphorylation P46734 (MAP2K3) phospho.ELM   PhosphoSitePlus 7839144, 9162092
S218 Phosphorylation Q16584 (MAP3K11) PhosphoSitePlus 9003778
S218 Phosphorylation Q7L7X3 (TAOK1) Signor 9786855
S218 Phosphorylation Q99683 (MAP3K5) PhosphoSitePlus   Signor 19920149
S218 Phosphorylation Q99759 (MAP3K3) Signor 9162092
S218 Phosphorylation Q9UL54 (TAOK2) Signor 11279118
T222 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   UniProt 9003778, 9162092, 8622669, ...7839144
T222 Phosphorylation P46734 (MAP2K3) phospho.ELM   PhosphoSitePlus 7839144, 9162092
T222 Phosphorylation Q16584 (MAP3K11) PhosphoSitePlus 9003778
Y230 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
K279 Sumoylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 19413330, 20068231
S6 Phosphorylation HPRD 20068231
S15 Phosphorylation HPRD 20068231
S218 Phosphorylation HPRD 20166139, 20058876, 8622669
T222 Phosphorylation HPRD 8622669
Site PTM Type PTM Enzyme Score Source PMID
S189 Phosphorylation HPRD   PRO 20166139, 20058876, 8622669
T193 Phosphorylation HPRD   PRO 8622669


P46734 (MAP2K3) as PTM Enzyme



Substrate Site Score Source PMID
O15264 (MAPK13) T180 neXtProt 9790884
O15264 (MAPK13) Y182 neXtProt 9790884
P46734 (MAP2K3) S218 phospho.ELM   PhosphoSitePlus 7839144, 9162092
P46734 (MAP2K3) T222 phospho.ELM   PhosphoSitePlus 7839144, 9162092
P53778 (MAPK12) T183 HPRD   neXtProt   phospho.ELM 11062067
P53778 (MAPK12) Y185 neXtProt   phospho.ELM 11062067
Q16539 (MAPK14) T180 HPRD   neXtProt   PhosphoSitePlus   Signor 18691976, 7839144, 19651622, ...17322306, 18669648, 8622669, 18767875, 11971971, 19920149, 20068231
Q16539 (MAPK14) Y182 neXtProt   PhosphoSitePlus   Signor 11971971, 7839144, 19920149, ...8622669


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048297 (hMAP2K3/Phos:1) pS218,pT222 PRO
PR:000036646 (hMAP2K3/iso:2/Phos:1) pS189,pT193 PRO 8622669