iPTMnet Report for P46695 (IER3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46695 / IEX1_HUMAN
Protein Name Radiation-inducible immediate-early gene IEX-1
Gene Name Name: IER3
Synonyms:DIF2,IEX1,PRG1;
Organism Homo sapiens (Human)

PRO ID PR:P46695
DAG View
PRO Name radiation-inducible immediate-early gene IEX-1 (human)
Definition A radiation-inducible immediate-early gene IEX-1 that is encoded in the genome of human.
Short Label hIER3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46695 (IER3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12356731
T18 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus   Signor 12356731
T18 Phosphorylation Q16659 (MAPK6) phospho.ELM 12356731
S31 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 27869121, 32157095
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K84 Ubiquitination PhosphoSitePlus
T123 Phosphorylation UniProt 12356731
S126 Phosphorylation UniProt 12356731
S146 O-Glycosylation GlyGen 25813380
T147 O-Glycosylation GlyGen 25813380


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S31 F31 Biomuta DOID:4159 / skin cancer [ cosmic ]
T123 N123 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S146 N146 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]