Protein Information

Cytoscape View


UniProt AC / UniProt ID P46459 / NSF_HUMAN
Protein Name Vesicle-fusing ATPase
Gene Name Name: NSF
Organism Homo sapiens (Human)

PRO ID PR:P46459
DAG View
PRO Name vesicle-fusing ATPase (human)
Definition A vesicle-fusing ATPase that is encoded in the genome of human.
Short Label hNSF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46459 (NSF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C21 S-Nitrosylation dbSNO 14567912, 22178444
Y45 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation P16591 (FER) , P07332 (FES) phospho.ELM   PhosphoSitePlus   RLIMS-P 15322554, 18067682
C91 S-Nitrosylation dbSNO 14567912, 22178444, 15944123
S106 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   UniProt 23186163
K217 Ubiquitination PhosphoSitePlus
S237 Phosphorylation RLIMS-P 26758690
C250 S-Nitrosylation dbSNO 16418269, 22178444
K254 Ubiquitination PhosphoSitePlus
C264 S-Nitrosylation dbSNO 22178444, 14567912, 24105792
K266 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
R337 Methylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S460 Phosphorylation Q02156 (PRKCE) neXtProt   RLIMS-P 20962217
T461 Phosphorylation Q02156 (PRKCE) neXtProt   RLIMS-P 20962217
K462 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
K489 Sumoylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
T534 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
T645 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus   RLIMS-P 26758690
T646 Phosphorylation RLIMS-P 26758690
S647 Phosphorylation RLIMS-P 26758690
T693 Phosphorylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
Y724 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S207 Phosphorylation HPRD 20068231
Y294 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46459 (NSF) Y83 P54920 (NAPA) inhibited_association eFIP 15322554


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K529 E529 Biomuta DOID:1324 / lung cancer [ cosmic ]
T534 K534 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
T645 I645 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S647 R647 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y724 C724 Biomuta DOID:263 / kidney cancer [ cosmic ]