iPTMnet Report for P46109 (CRKL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46109 / CRKL_HUMAN
Protein Name Crk-like protein
Gene Name Name: CRKL
Organism Homo sapiens (Human)

PRO ID PR:P46109
DAG View
PRO Name Crk-like protein (human)
Definition A Crk-like protein that is encoded in the genome of human.
Short Label hCRKL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46109 (CRKL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R11 Methylation PhosphoSitePlus
S41 Phosphorylation HPRD 20230923
S42 Phosphorylation HPRD   PhosphoSitePlus 20230923
T43 Phosphorylation HPRD   PhosphoSitePlus 20230923
C44 S-Nitrosylation dbSNO 26338901
Y48 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S107 Phosphorylation HPRD   PhosphoSitePlus 15345747
S112 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   RLIMS-P 34417497
Y127 Phosphorylation PhosphoSitePlus   UniProt 19690332
T130 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation HPRD   PhosphoSitePlus 17016520, 17389395
K145 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S184 Phosphorylation HPRD   PhosphoSitePlus 20068231
S185 Phosphorylation PhosphoSitePlus
S195 Phosphorylation HPRD   PhosphoSitePlus 20068231
S197 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y198 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17016520, 18669648, 17389395, ...27078848
Y207 Phosphorylation A9UF07 (BCR/ABL fusion) , A0A173G4P4 (Abl fusion) , P00519 (ABL1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17016520, 19901323, 22581121, ...20670950, 27078848, 9053848, 23691243, 23318429, 9710592, 15592455, 15268851, 20068231
T212 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T213 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S222 Phosphorylation HPRD   PhosphoSitePlus 20068231
T228 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation HPRD   PhosphoSitePlus 17016520
K253 Acetylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
T254 O-Glycosylation GlyGen 23301498, 34725712, 34019948, ...35132862, 32119511, 34229054
T254 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S42 T42 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S112 C112 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S114 L114 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T130 A130 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K145 T145 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y177 C177 Biomuta DOID:1324 / lung cancer [ cosmic ]
S195 F195 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S197 N197 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y198 C198 Biomuta DOID:1319 / brain cancer [ cosmic ]