Protein Information

Cytoscape View


UniProt AC / UniProt ID P46108 / CRK_HUMAN
Protein Name Adapter molecule crk
Gene Name Name: CRK
Organism Homo sapiens (Human)

PRO ID PR:P46108
DAG View
PRO Name adapter molecule crk (human)
Definition An adapter molecule crk that is encoded in the genome of human.
Short Label hCRK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46108 (CRK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S40 Phosphorylation PhosphoSitePlus   UniProt 23186163
S41 Phosphorylation Q13153 (PAK1) PhosphoSitePlus   RLIMS-P   UniProt 23186163, 20068231, 25956913, ...22848689
T42 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
S74 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S85 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus   UniProt 23186163
T111 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y136 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation P00533 (EGFR) , P00519 (ABL1) , P08069 (IGF1R) , A0A173G4P4 (Abl fusion) , P42684 (ABL2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9642287, 25860930, 17786281, ...21602891, 26656091, 9480911, 33215807, 10595738, 17399949, 17875741, 9480991, 16267043, 11406630, 8194526, 21779437, 12384576, 11839772, 8702917, 12955086, 22327338, 22848689, 25381819, 17515907, 12198159, 19001122
S225 Phosphorylation PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P   UniProt 15592455, 25381819
Y251 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P 21602891, 26473374, 25381819
K253 Acetylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 19415658, 20068231
S41 Phosphorylation HPRD 19651622, 15345747, 20068231
T42 Phosphorylation HPRD 19651622, 20068231
S74 Phosphorylation HPRD 18669648, 20068231
S83 Phosphorylation HPRD 18669648, 20068231
S85 Phosphorylation HPRD 20068231
S125 Phosphorylation HPRD 20068231
Y221 Phosphorylation P42684 (ABL2) , P00519 (ABL1) , P08069 (IGF1R) , P00533 (EGFR) HPRD 11956190, 17016520, 9642287, ...8875975, 9480911, 12198159, 20068231
Y239 Phosphorylation HPRD 15592455, 20068231
S304 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 19415658, 20068231
S41 Phosphorylation HPRD 19651622, 15345747, 20068231
T42 Phosphorylation HPRD 19651622, 20068231
S74 Phosphorylation HPRD 18669648, 20068231
S83 Phosphorylation HPRD 18669648, 20068231
S85 Phosphorylation HPRD 20068231
S125 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD   PhosphoSitePlus 20166139, 20068231
S196 Phosphorylation HPRD   PhosphoSitePlus 20068231


P46108 (CRK) as PTM Enzyme



Substrate Site Score Source PMID
Q05397-1 (PTK2) Y397 HPRD   Signor 17016520, 7509446, 7529876, ...12370821, 20068231, 11314030


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14654 (IRS4) Y743 P46108 (CRK) unknown eFIP 11316748
Phosphorylation O15117 (FYB1) Y595 P46108 (CRK) unknown eFIP 22074159
Phosphorylation P00519 (ABL1) Y226 P46108 (CRK) unknown eFIP 12384576
Phosphorylation P00533 (EGFR) Y1016 P46108 (CRK) unknown eFIP 16273093
Phosphorylation P04626 (ERBB2) Y1221 P46108 (CRK) unknown eFIP 16273093
Phosphorylation P09619 (PDGFRB) Y771 P46108 (CRK) unknown eFIP 10733900
Phosphorylation P10721 (KIT) Y900 P46108 (CRK) unknown eFIP 12878163
Phosphorylation P11362 (FGFR1) Y463 P46108 (CRK) unknown eFIP 10464310
Phosphorylation P16234 (PDGFRA) Y762 P46108 (CRK) unknown eFIP 10733900
Phosphorylation P16234 (PDGFRA) Y762 P46108 (CRK) unknown eFIP 9546424
Phosphorylation P21860 (ERBB3) Y1276 P46108 (CRK) unknown eFIP 16273093
Phosphorylation P22681 (CBL) Y774 P46108 (CRK) unknown eFIP 8626543
Phosphorylation P22681 (CBL) Y337 P46108 (CRK) unknown eFIP 8524328
Phosphorylation P36888 (FLT3) Y793 P46108 (CRK) unknown eFIP 28086240
Phosphorylation P43403 (ZAP70) Y315 P46108 (CRK) unknown eFIP 16339550
Phosphorylation P46108 (CRK) Y221 P00519 (ABL1) unknown eFIP 8702917
Phosphorylation P46108 (CRK) Y221 P00533 (EGFR) unknown eFIP 10595738
Phosphorylation P46108 (CRK) Y221 P56945 (BCAR1) inhibited_association eFIP 25860930
Phosphorylation P46108 (CRK) Y221 Q13905 (RAPGEF1) inhibited_association eFIP 19001122
Phosphorylation P46108 (CRK) Y221 P46108 (CRK) increased_association eFIP 12198159
Phosphorylation P49024 (PXN) Y31 P46108 (CRK) unknown eFIP 10704446
Phosphorylation Q08345 (DDR1) Y484 P46108 (CRK) unknown eFIP 22057045
Phosphorylation Q64010 (Crk) Y221 P46108 (CRK) unknown eFIP 8194526
Phosphorylation Q8IZP0 (ABI1) Y213 P46108 (CRK) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:10534 / stomach cancer [ tcga ]
S83 N83 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
S125 G125 Biomuta DOID:1324 / lung cancer [ cosmic ]
T228 I228 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]