iPTMnet Report for P46108 (CRK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46108 / CRK_HUMAN
Protein Name Adapter molecule crk
Gene Name Name: CRK
Organism Homo sapiens (Human)

PRO ID PR:P46108
DAG View
PRO Name adapter molecule crk (human)
Definition An adapter molecule crk that is encoded in the genome of human.
Short Label hCRK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46108 (CRK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S40 Phosphorylation PhosphoSitePlus   UniProt 23186163
S41 Phosphorylation Q13153 (PAK1) PhosphoSitePlus   RLIMS-P   UniProt 23186163, 20068231, 25956913, ...22848689
T42 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
S74 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S85 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus   UniProt 23186163
T111 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y136 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus   UniProt 20068231
S196 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation P00533 (EGFR) , P00519 (ABL1) , A0A173G4P4 (Abl fusion) , P08069 (IGF1R) , P42684 (ABL2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9642287, 25860930, 17786281, ...21602891, 26656091, 9480911, 33215807, 10595738, 17399949, 17875741, 9480991, 16267043, 11406630, 8194526, 21779437, 12384576, 11839772, 8702917, 12955086, 22327338, 22848689, 25381819, 17515907, 12198159, 19001122
S225 Phosphorylation PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P   UniProt 15592455, 25381819
Y251 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P 21602891, 26473374, 25381819
K253 Acetylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 19415658, 20068231
S41 Phosphorylation HPRD 19651622, 15345747, 20068231
T42 Phosphorylation HPRD 19651622, 20068231
S74 Phosphorylation HPRD 18669648, 20068231
S83 Phosphorylation HPRD 18669648, 20068231
S85 Phosphorylation HPRD 20068231
S125 Phosphorylation HPRD 20068231
Y221 Phosphorylation P00519 (ABL1) , P08069 (IGF1R) , P42684 (ABL2) , P00533 (EGFR) HPRD 11956190, 17016520, 9642287, ...8875975, 9480911, 12198159, 20068231
Y239 Phosphorylation HPRD 15592455, 20068231
S304 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 19415658, 20068231
S41 Phosphorylation HPRD 19651622, 15345747, 20068231
T42 Phosphorylation HPRD 19651622, 20068231
S74 Phosphorylation HPRD 18669648, 20068231
S83 Phosphorylation HPRD 18669648, 20068231
S85 Phosphorylation HPRD 20068231
S125 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD   PhosphoSitePlus 20166139, 20068231
S196 Phosphorylation HPRD   PhosphoSitePlus 20068231


P46108 (CRK) as PTM Enzyme



Substrate Site Score Source PMID
Q05397 (PTK2) Y397 HPRD   Signor 17016520, 7509446, 7529876, ...12370821, 20068231, 11314030


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P22681 (CBL) Y774 P46108 (CRK) unknown eFIP 34062268
Phosphorylation P46108 (CRK) Y221 P00533 (EGFR) unknown eFIP 10595738
Phosphorylation P46108 (CRK) Y221 P46108 (CRK) increased_association eFIP 12198159
Phosphorylation P46108 (CRK) Y221 P56945 (BCAR1) inhibited_association eFIP 25860930
Phosphorylation P46108 (CRK) Y221 P00519 (ABL1) unknown eFIP 8702917
Phosphorylation P46108 (CRK) Y221 Q13905 (RAPGEF1) inhibited_association eFIP 19001122


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S83 N83 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S83 I83 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S96 L96 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
T112 A112 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S121 F121 Biomuta DOID:4159 / skin cancer [ cosmic ]
S125 G125 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S194 F194 Biomuta DOID:4159 / skin cancer [ cosmic ]
S196 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S208 F208 Biomuta DOID:4159 / skin cancer [ cosmic ]
T228 I228 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y239 F239 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]