iPTMnet Report for P46087 (NOP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46087 / NOP2_HUMAN
Protein Name Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
Gene Name Name: NOP2
Synonyms:NOL1,NSUN1;
Organism Homo sapiens (Human)

PRO ID PR:P46087
DAG View
PRO Name probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (human)
Definition A probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase that is encoded in the genome of human.
Short Label hNOP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46087 (NOP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K22 Methylation PhosphoSitePlus
S36 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S40 Phosphorylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...18669648, 17081983
T64 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S67 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17924679
K71 Sumoylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 17081983, ...16565220, 18669648, 2256932, 19690332, 20068231
T185 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 17081983, ...18669648, 20068231, 19690332, 2256932
T195 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935
S198 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K340 Acetylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K482 Acetylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
T573 O-Glycosylation GlyGen 33214551, 34725712, 32522876, ...29351928, 34019948, 31373491, 32119511, 34229054
T596 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T603 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16565220
T605 Phosphorylation PhosphoSitePlus
K615 Sumoylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K649 Acetylation PhosphoSitePlus   UniProt 19608861
S659 O-Glycosylation GlyGen 31373491
S666 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T668 O-Glycosylation GlyGen 33214551, 34725712, 32522876, ...29351928, 34019948, 31373491, 32119511, 34229054
T670 O-Glycosylation GlyGen 31373491
S675 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S679 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
K704 Acetylation PhosphoSitePlus
T727 Phosphorylation PhosphoSitePlus
S732 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...16565220, 18669648, 19690332, 20068231, 17081983
S734 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T736 Phosphorylation PhosphoSitePlus
T739 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K767 Ubiquitination PhosphoSitePlus
K772 Acetylation PhosphoSitePlus
T776 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T784 Phosphorylation PhosphoSitePlus
S786 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 20068231
S801 Phosphorylation PhosphoSitePlus   UniProt 21406692
S803 Phosphorylation PhosphoSitePlus
R804 Methylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
S812 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation HPRD 18669648
S58 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 19691289, 19007248, 18669648, 20068231, 18212344
T64 Phosphorylation HPRD 19664995, 18669648, 19691289, ...19007248
S67 Phosphorylation HPRD 18691976, 19691289, 19007248, ...19664995, 18669648, 17924679, 20068231, 20068230
S107 Phosphorylation HPRD 17081983
S116 Phosphorylation HPRD 17081983
S130 Phosphorylation HPRD 17081983
T136 Phosphorylation HPRD 17081983
S146 Phosphorylation HPRD 17081983
S177 Phosphorylation HPRD 18691976, 16565220, 18669648, ...18452278, 19415658, 20068231
T181 Phosphorylation HPRD 18691976, 17081983, 18452278, ...18669648, 19415658, 20068231
T191 Phosphorylation HPRD 19413330, 15302935, 19007248, ...16565220, 18452278, 20068231, 19691289
S194 Phosphorylation HPRD 19413330
S258 Phosphorylation HPRD 19691289
T501 Phosphorylation HPRD 20068231
S502 Phosphorylation HPRD 20068231
T592 Phosphorylation HPRD 18669648
T599 Phosphorylation HPRD 18669648, 20068231, 16565220
S662 Phosphorylation HPRD 18669648
S671 Phosphorylation HPRD 19413330, 18669648, 19007248, ...19691289
T719 Phosphorylation HPRD 20068231
T723 Phosphorylation HPRD 19413330
S728 Phosphorylation HPRD 19413330, 18691976, 19691289, ...17287340, 16964243, 18767875, 19664994, 19007248, 18452278, 19651622, 18669648, 19664995, 16565220, 19415658, 20068231, 20068230
S730 Phosphorylation HPRD 19413330, 18767875, 19664995, ...17322306, 18669648, 17924679
T735 Phosphorylation HPRD 18669648
T772 Phosphorylation HPRD 18669648, 20068231
T780 Phosphorylation HPRD 20068231
S782 Phosphorylation HPRD 19413330, 18691976, 19691289, ...17081983, 20058876, 15302935, 19007248, 19664995, 19651622, 18669648, 20068231, 20068230
S797 Phosphorylation HPRD 20068231
S808 Phosphorylation HPRD 19413330, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S67 F67 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T136 M136 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S148 F148 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T191 A191 Biomuta DOID:363 / uterine cancer [ icgc ]
T195 A195 Biomuta DOID:363 / uterine cancer [ icgc ]
S264 F264 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K471 N471 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K482 N482 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S659 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S662 F662 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S666 F666 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K704 N704 Biomuta DOID:4159 / skin cancer [ cosmic ]
T723 A723 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T727 A727 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T735 I735 Biomuta DOID:4159 / skin cancer [ cosmic ]
T739 I739 Biomuta DOID:4159 / skin cancer [ cosmic ]
T772 A772 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T776 A776 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S797 F797 Biomuta DOID:363 / uterine cancer [ icgc ]
S797 Y797 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S801 F801 Biomuta DOID:363 / uterine cancer [ icgc ]
S801 Y801 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S807 R807 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S808 F808 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S812 F812 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]