Protein Information

Cytoscape View


UniProt AC / UniProt ID P46063 / RECQ1_HUMAN
Protein Name ATP-dependent DNA helicase Q1
Gene Name Name: RECQL
Synonyms:RECQ1,RECQL1;
Organism Homo sapiens (Human)

PRO ID PR:P46063
DAG View
PRO Name ATP-dependent DNA helicase Q1 (human)
Definition An ATP-dependent DNA helicase Q1 that is encoded in the genome of human.
Short Label hRECQL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46063 (RECQL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K88 Methylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K91 Methylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S166 Phosphorylation HPRD 20068231
K167 Ubiquitination PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
Y208 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y235 Phosphorylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K313 Methylation PhosphoSitePlus
K380 Acetylation PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K487 Methylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K509 Acetylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K514 Acetylation PhosphoSitePlus   UniProt 19608861
K514 Ubiquitination PhosphoSitePlus
K522 Acetylation PhosphoSitePlus   UniProt 19608861
K522 Ubiquitination PhosphoSitePlus
Y554 Phosphorylation PhosphoSitePlus
Y559 Phosphorylation PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus   UniProt 23186163
S602 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
C606 S-Nitrosylation dbSNO 26338901
S608 Phosphorylation PhosphoSitePlus
K613 Acetylation PhosphoSitePlus
K614 Acetylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
S634 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S636 Phosphorylation HPRD 20068231
K637 Ubiquitination PhosphoSitePlus
K642 Acetylation PhosphoSitePlus
K643 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K185 R185 Biomuta DOID:263 / kidney cancer [ tcga ]
Y208 F208 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K452 R452 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K487 N487 Biomuta DOID:9256 / colorectal cancer [ icgc ]
C606 F606 Biomuta DOID:3571 / liver cancer [ icgc ]
S608 A608 Biomuta DOID:1324 / lung cancer [ tcga ]
K642 T642 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K642 N642 Biomuta DOID:363 / uterine cancer [ tcga ]