Protein Information

Cytoscape View

UniProt AC / UniProt ID P46060 / RAGP1_HUMAN
Protein Name Ran GTPase-activating protein 1
Gene Name Name: RANGAP1
Organism Homo sapiens (Human)

PRO ID PR:P46060
DAG View
PRO Name Ran GTPase-activating protein 1 (human)
Definition A Ran GTPase-activating protein 1 that is encoded in the genome of human.
Short Label hRANGAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P46060 (RANGAP1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 20388717
S3 Phosphorylation PhosphoSitePlus
K8 Sumoylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S24 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K26 Acetylation PhosphoSitePlus
K26 Sumoylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K28 Sumoylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
R81 Methylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
C169 S-Nitrosylation dbSNO 19483679
K172 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
R289 Methylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus   UniProt 23186163
K306 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
S358 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 16428860
K406 Methylation PhosphoSitePlus
T409 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15037602
K413 Acetylation PhosphoSitePlus
T419 Phosphorylation HPRD 20068231
S427 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231, ...18452278
S428 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 17081983, 15302935, ...19664995, 18452278, 18669648, 19415658, 15037602, 16565220, 19690332, 20068231
S435 Phosphorylation PhosphoSitePlus   UniProt 19690332
T436 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 19690332, ...20068231
S442 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 21406692, 23186163, ...17081983, 15302935, 19664995, 18452278, 19651622, 18669648, 15037602, 19690332, 17693683, 16565220, 19415658, 20068231
K452 Sumoylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S453 Phosphorylation HPRD   PhosphoSitePlus 18452278
T461 Phosphorylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
S478 Phosphorylation HPRD   PhosphoSitePlus 20068231, 20068230
K481 Ubiquitination PhosphoSitePlus
T485 Phosphorylation HPRD   PhosphoSitePlus 20068230
S505 Phosphorylation PhosphoSitePlus
K524 Acetylation PhosphoSitePlus   UniProt 19608861
K524 Sumoylation PRO   PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K528 Sumoylation PhosphoSitePlus
K530 Sumoylation PhosphoSitePlus
Y585 Phosphorylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049012 (hRANGAP1/InitMet-/Sumo:1) suK524 PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14980 (XPO1) S391 P46060 (RANGAP1) increased_association eFIP 23729730

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K31 R31 Biomuta DOID:1324 / lung cancer [ cosmic ]
K178 R178 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K178 N178 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S301 * Biomuta DOID:363 / uterine cancer [ tcga ]
S358 C358 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T436 I436 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S478 F478 Biomuta DOID:1324 / lung cancer [ tcga ]
K530 N530 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]