iPTMnet Report for P45974 (USP5)
Protein Information
| UniProt AC / UniProt ID | P45974 / UBP5_HUMAN |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 5 |
| Gene Name | Name: USP5 Synonyms:ISOT; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P45974 |
| PRO Name | ubiquitin carboxyl-terminal hydrolase 5 (human) |
| Definition | A ubiquitin carboxyl-terminal hydrolase 5 that is encoded in the genome of human. |
| Short Label | hUSP5 |
| Category | organism-gene |
P45974 (USP5) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 19413330, 22814378, 22223895 | ||
| S5 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K27 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y57 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T65 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K121 | Sumoylation | score1 | PhosphoSitePlus | |||
| Y128 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S156 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S159 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K163 | Acetylation | score1 | PhosphoSitePlus | |||
| K163 | Sumoylation | score1 | PhosphoSitePlus | |||
| K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K178 | Acetylation | score1 | PhosphoSitePlus | |||
| K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S182 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K184 | Acetylation | score1 | PhosphoSitePlus | |||
| K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T213 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S216 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K247 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T289 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K291 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T292 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K353 | Acetylation | score1 | PhosphoSitePlus | |||
| K353 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K357 | Acetylation | score1 | PhosphoSitePlus | |||
| K357 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K360 | Sumoylation | score1 | PhosphoSitePlus | |||
| K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K379 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y389 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K391 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K406 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K423 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S453 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K468 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K470 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K476 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y479 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y485 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K499 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y505 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K508 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K516 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C532 | Methylation | score1 | IEDB | 31844290 | ||
| K553 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K558 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T559 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K574 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K575 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K585 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K586 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T623 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16964243 | ||
| S658 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K743 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S779 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S783 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 19690332, ... | ||
| S785 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S787 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K793 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K836 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K842 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K845 | Ubiquitination | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S161 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T213 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S216 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y485 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y505 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T623 | Phosphorylation | score0 | HPRD | 18510355, 16964243 | ||
| S779 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S783 | Phosphorylation | score0 | HPRD | 18212344, 18767875, 20058876, ... |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S161 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T213 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S216 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y485 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y505 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T623 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18510355, 16964243 | ||
| S635 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
| S756 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S760 | Phosphorylation | score0 | HPRD | 18212344, 18767875, 20058876, ... |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S5 | T5 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S5 | G5 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K80 | R80 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K80 | E80 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S182 | N182 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K247 | T247 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K291 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| K291 | N291 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K379 | T379 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S453 | N453 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y479 | N479 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K575 | N575 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S785 | A785 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S787 | P787 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| S787 | F787 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] |
DAG View