Protein Information

Cytoscape View


UniProt AC / UniProt ID P45973 / CBX5_HUMAN
Protein Name Chromobox protein homolog 5
Gene Name Name: CBX5
Synonyms:HP1A;
Organism Homo sapiens (Human)

PRO ID PR:P45973
DAG View
PRO Name chromobox protein homolog 5 (human)
Definition A chromobox protein homolog 5 that is encoded in the genome of human.
Short Label hCBX5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P45973 (CBX5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 17287340, ...17081983
S11 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17287340, 17081983, 21245376, ...18452278, 19651622, 18669648, 24275569, 19690332, 20068231
S12 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17081983, 19691289, 18452278, ...19651622, 18669648, 24275569, 21245376, 20068231
S13 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17287340, 17081983, ...19691289, 18452278, 19651622, 18669648, 24275569, 21245376, 20068231
S14 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17287340, 17081983, ...21245376, 18452278, 19651622, 18669648, 24275569, 23186163, 19690332, 20068231
Y20 Phosphorylation PhosphoSitePlus
K32 Methylation PhosphoSitePlus
K32 Sumoylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K40 Methylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K91 Methylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S92 Phosphorylation Q96GD4 (AURKB) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17287340, 18212344, ...19691289, 19007248, 22067460, 18669648, 22267324, 23186163, 19690332, 20068231, 17924679
S95 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24619172, 21406692, 23186163
S97 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19691289, 19007248, ...19690332, 20068231
K102 Sumoylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S110 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 20068231
R115 Methylation PhosphoSitePlus
R119 Methylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K143 Acetylation PhosphoSitePlus
K143 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K154 Methylation PhosphoSitePlus
K154 Sumoylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044878 (hHIST1H1E/InitMet-/Me1:1) Interaction PR:P45973 (hCBX5) PRO 16127177
PR:000045400 (hHIST1H1E/InitMet-/Me1Phos:1) NOT Interaction PR:P45973 (hCBX5) PRO 16127177
PR:P45973 (hCBX5) Interaction PR:000044878 (hHIST1H1E/InitMet-/Me1:1) PRO 16127177
PR:P45973 (hCBX5) NOT Interaction PR:000045400 (hHIST1H1E/InitMet-/Me1Phos:1) PRO 16127177


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K40 T40 Biomuta DOID:363 / uterine cancer [ tcga ]
S95 L95 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R115 W115 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:3070 / malignant glioma [ tcga ]
T130 P130 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S191 I191 Biomuta DOID:1909 / melanoma [ tcga ]