Protein Information

Cytoscape View


UniProt AC / UniProt ID P45880 / VDAC2_HUMAN
Protein Name Voltage-dependent anion-selective channel protein 2
Gene Name Name: VDAC2
Organism Homo sapiens (Human)

PRO ID PR:P45880
DAG View
PRO Name voltage-dependent anion-selective channel protein 2 (human)
Definition A voltage-dependent anion-selective channel protein 2 that is encoded in the genome of human.
Short Label hVDAC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P45880 (VDAC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
A2 Acetylation UniProt 19413330, 25944712
T7 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus   UniProt 19608861
K31 Ubiquitination PhosphoSitePlus   UniProt 25621951
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
C47 S-Nitrosylation dbSNO 2212679, 22126794, 22178444, ...20140087
S48 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K64 Sumoylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus   UniProt 25621951
T66 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus   UniProt 25621951
Y73 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
C76 S-Nitrosylation dbSNO 22178444, 19366988, 18335467
Y78 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
S115 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T118 Phosphorylation PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus   UniProt 25621951
K121 Ubiquitination PhosphoSitePlus   UniProt 25621951
K124 Ubiquitination UniProt 25621951
S128 Phosphorylation PhosphoSitePlus
K172 Sumoylation PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S251 O-Glycosylation GlyGen 23301498, 27655845, 30397120, ...29351928, 24120863, 32119511, 28510447
S251 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
T259 O-Glycosylation GlyGen 23301498, 27655845, 30397120, ...29351928, 24120863, 32119511, 28510447
T259 Phosphorylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
K277 Methylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus   UniProt 25621951
K285 Acetylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus   UniProt 25621951
Site PTM Type PTM Enzyme Score Source PMID
T113 Phosphorylation HPRD 20068231
S115 Phosphorylation HPRD 19413330, 18578522, 18088087, ...17081983, 18767875, 19664994, 19691289, 19651622, 18669648, 20068231
T118 Phosphorylation HPRD 18767875, 17081983, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049652 (hVDAC2/InitMet-/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S58 F58 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C76 Y76 Biomuta DOID:2531 / hematologic cancer [ tcga ]
T112 A112 Biomuta DOID:2531 / hematologic cancer [ tcga ]
T113 A113 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S115 T115 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S251 C251 Biomuta DOID:184 / bone cancer [ icgc ]