iPTMnet Report for P45877 (PPIC)
Protein Information
UniProt AC / UniProt ID | P45877 / PPIC_HUMAN |
Protein Name | Peptidyl-prolyl cis-trans isomerase C |
Gene Name | Name: PPIC Synonyms:CYPC; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P45877 |
PRO Name | peptidyl-prolyl cis-trans isomerase C (human) |
Definition | A eukaryotic-type peptidyl-prolyl cis-trans isomerase C that is encoded in the genome of human. |
Short Label | hPPIC |
Category | organism-gene |
P45877 (PPIC) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S35 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
R45 | Methylation | score1 | PhosphoSitePlus | |||
K65 | Ubiquitination | score1 | PhosphoSitePlus | |||
K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
K123 | Methylation | score1 | PhosphoSitePlus | |||
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
N190 | N-Glycosylation | score1 | GlyGen | 29741879, 32125861 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S35 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S35 | L35 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K123 | N123 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
N190 | D190 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
N190 | S190 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] |