iPTMnet Report for P45877 (PPIC)
Protein Information
| UniProt AC / UniProt ID | P45877 / PPIC_HUMAN |
| Protein Name | Peptidyl-prolyl cis-trans isomerase C |
| Gene Name | Name: PPIC Synonyms:CYPC; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P45877 |
| PRO Name | peptidyl-prolyl cis-trans isomerase C (human) |
| Definition | A eukaryotic-type peptidyl-prolyl cis-trans isomerase C that is encoded in the genome of human. |
| Short Label | hPPIC |
| Category | organism-gene |
DAG ViewP45877 (PPIC) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S35 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
| R45 | Methylation | score1 | PhosphoSitePlus | |||
| K65 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K123 | Methylation | score1 | PhosphoSitePlus | |||
| K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N190 | N-Glycosylation | score1 | GlyGen | 29741879, 32125861 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S35 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S35 | L35 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K123 | N123 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| N190 | D190 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| N190 | S190 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] |
