iPTMnet Report for P43354 (NR4A2)
Protein Information
UniProt AC / UniProt ID | P43354 / NR4A2_HUMAN |
Protein Name | Nuclear receptor subfamily 4 group A member 2 |
Gene Name | Name: NR4A2 Synonyms:NOT,NURR1,TINUR; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P43354 |
PRO Name | nuclear receptor subfamily 4 group A member 2 (human) |
Definition | A nuclear receptor subfamily 4 group A member 2 that is encoded in the genome of human. |
Short Label | hNR4A2 |
Category | organism-gene |
P43354 (NR4A2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y71 | Phosphorylation | score1 | PhosphoSitePlus | |||
S125 | Phosphorylation | score1 | PhosphoSitePlus | |||
S126 | Phosphorylation | P28482 (MAPK1) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 24223135, 17681692 | |
T129 | Phosphorylation | score1 | PhosphoSitePlus | |||
T132 | Phosphorylation | P28482 (MAPK1) | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 17681692 | |
S177 | Phosphorylation | score1 | PhosphoSitePlus | |||
S181 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 24223135, 17081983 | ||
T185 | Phosphorylation | score1 | PhosphoSitePlus | |||
K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
S250 | Phosphorylation | score1 | PhosphoSitePlus | |||
S256 | Phosphorylation | score1 | PhosphoSitePlus | |||
S258 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y275 | Phosphorylation | score1 | PhosphoSitePlus | |||
T279 | Phosphorylation | score1 | PhosphoSitePlus | |||
K296 | Ubiquitination | score1 | PhosphoSitePlus | |||
K303 | Ubiquitination | score1 | PhosphoSitePlus | |||
T335 | Phosphorylation | score1 | PhosphoSitePlus | |||
S337 | Phosphorylation | P78527 (PRKDC) | score3 | neXtProt PhosphoSitePlus | 21979916 | |
S347 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 19522012 | ||
S351 | Phosphorylation | score1 | PhosphoSitePlus | |||
S356 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S359 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S363 | Phosphorylation | score1 | PhosphoSitePlus | |||
K530 | Ubiquitination | score1 | PhosphoSitePlus | |||
K558 | Sumoylation | score1 | PhosphoSitePlus | |||
K558 | Ubiquitination | score1 | PhosphoSitePlus | |||
K577 | Sumoylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S126 | L126 | Biomuta | DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] | |
T129 | M129 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S181 | L181 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T185 | I185 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y275 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] | |
Y275 | H275 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
T279 | I279 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S347 | L347 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S356 | F356 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
S359 | L359 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] |