iPTMnet Report for P43246 (MSH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43246 / MSH2_HUMAN
Protein Name DNA mismatch repair protein Msh2
Gene Name Name: MSH2
Organism Homo sapiens (Human)

PRO ID PR:P43246
DAG View
PRO Name DNA mismatch repair protein Msh2 (human)
Definition A DNA mismatch repair protein Msh2 that is encoded in the genome of human.
Short Label hMSH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43246 (MSH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K65 Ubiquitination PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Methylation PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
R219 Methylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus   RLIMS-P 25978431
K249 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K430 Sumoylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K550 Acetylation PhosphoSitePlus
K555 Acetylation PhosphoSitePlus   UniProt 19608861
K555 Sumoylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
Y563 Phosphorylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
K567 Sumoylation PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
K635 Acetylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
C707 Methylation IEDB 31844290
S717 Phosphorylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
T740 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
C843 Methylation IEDB 31844290
K845 Ubiquitination PhosphoSitePlus
Y856 Phosphorylation PhosphoSitePlus
S860 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Y863 Phosphorylation PhosphoSitePlus
K871 Ubiquitination PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
T897 Phosphorylation PhosphoSitePlus
S900 Phosphorylation PhosphoSitePlus
K912 Ubiquitination PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
T32 Phosphorylation HPRD 20068231
T206 Phosphorylation HPRD 20068231
T732 Phosphorylation HPRD 20068231
S734 Phosphorylation HPRD 20068231
S860 Phosphorylation HPRD 17525332
T897 Phosphorylation HPRD 19562805
S900 Phosphorylation HPRD 19562805


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
A2 E2 Biomuta DOID:4159 / skin cancer [ cosmic ]
A2 G2 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K73 N73 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S77 I77 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K172 R172 Biomuta DOID:363 / uterine cancer [ icgc ]
K172 * Biomuta DOID:9256 / colorectal cancer [ civic ]
R219 I219 Biomuta DOID:363 / uterine cancer [ icgc ]
Y238 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K249 M249 Biomuta DOID:1324 / lung cancer [ cosmic ]
K347 N347 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K550 T550 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y570 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C707 Y707 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C707 R707 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S717 N717 Biomuta DOID:4159 / skin cancer [ cosmic ]
K741 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S743 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S743 L743 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y856 C856 Biomuta DOID:1324 / lung cancer [ cosmic ]
K871 N871 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ]
T897 I897 Biomuta DOID:4159 / skin cancer [ cosmic ]
S900 L900 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K918 N918 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S921 R921 Biomuta DOID:10283 / prostate cancer [ cosmic ]