iPTMnet Report for P43243 (MATR3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43243 / MATR3_HUMAN
Protein Name Matrin-3
Gene Name Name: MATR3
Synonyms:KIAA0723;
Organism Homo sapiens (Human)

PRO ID PR:P43243
DAG View
PRO Name matrin-3 (human)
Definition A matrin-3 that is encoded in the genome of human.
Short Label hMATR3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43243 (MATR3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation PhosphoSitePlus
K3 Acetylation IEDB   PhosphoSitePlus   UniProt 34357683, 19608861
K3 Methylation PhosphoSitePlus
K3 Sumoylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
S4 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 21406692, 23186163, 21851590, ...24275569, 20068231
S8 Phosphorylation PhosphoSitePlus
S9 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S11 Phosphorylation PhosphoSitePlus   UniProt 23186163
S14 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S22 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S22 Phosphorylation PhosphoSitePlus   UniProt 19690332
T33 O-Glycosylation GlyGen 27655845, 30444036, 32938750, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 28510447, 32119511, 35289036, 35254053, 22121020, 31373491
S35 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S37 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S37 Phosphorylation PhosphoSitePlus
S41 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S41 Phosphorylation PhosphoSitePlus   UniProt 20068231
T49 Phosphorylation PhosphoSitePlus
R51 Methylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S61 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S63 Phosphorylation PhosphoSitePlus
S71 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S71 Phosphorylation PhosphoSitePlus
S74 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S75 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S75 Phosphorylation PhosphoSitePlus
S77 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
S77 Phosphorylation PhosphoSitePlus
S85 O-Glycosylation GlyGen 27655845, 30444036, 28510447, ...30397120, 34725712, 26853435, 33214551, 28657654, 29351928, 34019948, 35083852, 32870666, 22967762, 32119511, 35289036, 35254053, 22121020, 31373491
R92 Methylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S126 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y128 Phosphorylation PhosphoSitePlus
K132 Sumoylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Sumoylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T150 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 21851590, 23186163, 24275569
T155 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y158 Phosphorylation PhosphoSitePlus   UniProt 23186163
S164 Phosphorylation PhosphoSitePlus   UniProt 23186163
T166 Phosphorylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
K181 Acetylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S188 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18318008, 27920218, 18669648, 24275569, 17287340, 20068231, 17924679
R192 Methylation PhosphoSitePlus
S195 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...18220336, 18669648, 21851590, 23186163, 20068231
Y202 Phosphorylation PhosphoSitePlus   UniProt 23186163
S206 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 24275569, 20068231
S208 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692, ...20068231
S211 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y213 Phosphorylation PhosphoSitePlus
Y214 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R216 Methylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus   UniProt 21406692
R223 Methylation PhosphoSitePlus
C230 S-Nitrosylation dbSNO 26338901
S234 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T239 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K245 Sumoylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
R255 Methylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus   UniProt 23186163
K269 Sumoylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus   UniProt 23186163
S276 Phosphorylation PhosphoSitePlus
K304 Acetylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
R387 Methylation PhosphoSitePlus
S397 Phosphorylation phospho.ELM 17081983
R407 Methylation PhosphoSitePlus
Y413 Phosphorylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
K473 Acetylation PhosphoSitePlus
K473 Sumoylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
K478 Acetylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K479 Acetylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K487 Acetylation PhosphoSitePlus
K487 Sumoylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K491 Acetylation PhosphoSitePlus
K491 Sumoylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus   UniProt 23186163
S511 Phosphorylation PhosphoSitePlus   UniProt 23186163
K515 Sumoylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
K522 Acetylation PhosphoSitePlus   UniProt 19608861
K522 Sumoylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K524 Sumoylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
S533 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
C552 Methylation IEDB 31844290
K554 Ubiquitination PhosphoSitePlus
K555 Sumoylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K565 Acetylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
K571 Acetylation PhosphoSitePlus   UniProt 19608861
K571 Ubiquitination PhosphoSitePlus
K573 Acetylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K588 Sumoylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
S596 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 15302935, ...17081983
Y597 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S598 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 15302935, 18669648, 24275569, 20068231
K602 Methylation PhosphoSitePlus
S604 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 15302935, 18669648, 24275569, 20068231
S606 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K608 Methylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
K617 Acetylation PhosphoSitePlus
K617 Sumoylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
T622 Phosphorylation PhosphoSitePlus
K625 Acetylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus
K640 Sumoylation PhosphoSitePlus
T644 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S654 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
S671 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
S673 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
S674 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
T679 Phosphorylation PhosphoSitePlus   UniProt 24275569
S689 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
K692 Acetylation PhosphoSitePlus
K692 Sumoylation PhosphoSitePlus
S696 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K702 Acetylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
K711 Acetylation PhosphoSitePlus
K712 Acetylation PhosphoSitePlus
K713 Acetylation PhosphoSitePlus
K715 Sumoylation PhosphoSitePlus
K716 Sumoylation PhosphoSitePlus
K719 Sumoylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
K736 Sumoylation PhosphoSitePlus
T741 Phosphorylation PhosphoSitePlus   UniProt 21406692
S747 Phosphorylation PhosphoSitePlus   UniProt 21406692
S748 Phosphorylation PhosphoSitePlus
T758 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
S766 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
K770 Sumoylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
Y773 Phosphorylation PhosphoSitePlus
Y779 Phosphorylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
Y794 Phosphorylation PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
Y802 Phosphorylation PhosphoSitePlus
K804 Methylation PhosphoSitePlus
C806 S-Nitrosylation dbSNO 20140087, 22178444, 19366988, ...18335467
T811 Phosphorylation PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
Y827 Phosphorylation PhosphoSitePlus
K829 Acetylation PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K831 Acetylation PhosphoSitePlus
K836 Acetylation PhosphoSitePlus   UniProt 19608861
K836 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 20068231
S9 Phosphorylation HPRD 18669648
S14 Phosphorylation HPRD 20068231
S41 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 20068231
S98 Phosphorylation HPRD 20068231
S157 Phosphorylation HPRD 20068231
Y158 Phosphorylation HPRD 20068231
S164 Phosphorylation HPRD 20068231
Y171 Phosphorylation HPRD 17081983
S188 Phosphorylation HPRD 18691976, 17287340, 17081983, ...20230923, 20058876, 19664995, 18452278, 19651622, 18510355, 18669648, 18707149, 20166139, 20068231, 17924679
S195 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20166139, 20068231
Y202 Phosphorylation HPRD 17081983
S206 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S208 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231, 18452278
Y214 Phosphorylation HPRD 18669648
S234 Phosphorylation HPRD 20068231
T239 Phosphorylation HPRD 17081983
S240 Phosphorylation HPRD 17081983
Y243 Phosphorylation HPRD 17081983
S397 Phosphorylation HPRD 17081983
S533 Phosphorylation HPRD 18669648, 18212344, 20068231
S596 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
Y597 Phosphorylation HPRD 18669648, 17081983, 20068231
S598 Phosphorylation HPRD 15302935, 19664995, 18452278, ...19651622, 18669648, 20166139, 20068231
S604 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231, 18452278
S606 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
T639 Phosphorylation HPRD 17081983, 20068231
T644 Phosphorylation HPRD 18691976, 17081983, 20068231
S654 Phosphorylation HPRD 18691976, 17081983, 20068231
S671 Phosphorylation HPRD 18691976, 17081983, 20068231
S673 Phosphorylation HPRD 18691976, 17081983, 20068231
S674 Phosphorylation HPRD 18691976, 17081983, 20068231
T679 Phosphorylation HPRD 17081983
S689 Phosphorylation HPRD 18691976, 17081983, 20068231
S748 Phosphorylation HPRD 18452278
T758 Phosphorylation HPRD 18452278
S759 Phosphorylation HPRD 18452278
S766 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
Y773 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 G11 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R51 C51 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S85 F85 Biomuta DOID:4159 / skin cancer [ cosmic ]
S98 F98 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T166 A166 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R192 C192 Biomuta DOID:363 / uterine cancer [ icgc ]
S195 T195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R216 K216 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S234 F234 Biomuta DOID:4159 / skin cancer [ cosmic ]
S240 W240 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y250 C250 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R255 C255 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ]
S264 P264 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R387 G387 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y413 C413 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K478 N478 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S506 C506 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K573 I573 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S598 Y598 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K602 R602 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S606 R606 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K608 N608 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S610 Y610 Biomuta [ cosmic ]
S615 F615 Biomuta DOID:1319 / brain cancer [ icgc ]
K712 T712 Biomuta DOID:363 / uterine cancer [ icgc ]
K715 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K770 N770 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y773 C773 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T811 I811 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K829 N829 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]