iPTMnet Report for P43121 (MCAM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43121 / MUC18_HUMAN
Protein Name Cell surface glycoprotein MUC18 precursor
Gene Name Name: MCAM
Synonyms:MUC18;
Organism Homo sapiens (Human)

PRO ID PR:P43121
DAG View
PRO Name cell surface glycoprotein MUC18 (human)
Definition A cell surface glycoprotein MUC18 that is encoded in the genome of human.
Short Label hMCAM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43121 (MCAM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N56 N-Glycosylation GlyGen 23090970, 24190977
S93 Phosphorylation PhosphoSitePlus
R97 Methylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S413 O-Glycosylation GlyGen 30379171, 33214551, 34725712, ...34019948, 35289036
N418 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N445 N-Glycosylation GlyGen 24190977
N449 N-Glycosylation GlyGen 23090970, 24190977
N467 N-Glycosylation GlyGen   UniProt 19159218
K585 Acetylation PhosphoSitePlus
S593 O-Glycosylation GlyGen 30379171, 33214551, 34725712, ...34019948, 35289036
K605 Acetylation PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
S606 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K613 Acetylation PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
S614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
K616 Ubiquitination PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus   UniProt 20068231
K631 Ubiquitination PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
Y641 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y202 Phosphorylation HPRD 20068231
S606 Phosphorylation HPRD 18578522, 18669648
S614 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S628 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S123 Y123 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y126 D126 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S606 C606 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S628 N628 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]