Protein Information

Cytoscape View


UniProt AC / UniProt ID P43034 / LIS1_HUMAN
Protein Name Platelet-activating factor acetylhydrolase IB subunit alpha
Gene Name Name: PAFAH1B1
Synonyms:LIS1;
Organism Homo sapiens (Human)

PRO ID PR:P43034
DAG View
PRO Name platelet-activating factor acetylhydrolase IB subunit alpha (human)
Definition A platelet-activating factor acetylhydrolase IB subunit alpha that is encoded in the genome of human.
Short Label hPAFAH1B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43034 (PAFAH1B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus   UniProt 19608861
K53 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus   UniProt 23186163
T131 Phosphorylation RLIMS-P 21677187
K147 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
R234 Methylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
R363 Methylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y225 Phosphorylation HPRD 17693683


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 C57 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K71 R71 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S253 C253 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S304 N304 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R363 H363 Biomuta DOID:1909 / melanoma [ cosmic ]